Assembly of a bipolar mitotic spindle is essential to ensure accurate chromosome segregation and prevent aneuploidy, and severe mitotic spindle defects are typically associated with cell death. Recent studies have shown that mitotic spindles with initial geometric defects can undergo specific rearrangements so the cell can complete mitosis with a bipolar spindle and undergo bipolar chromosome segregation, thus preventing the risk of cell death associated with abnormal spindle structure. Although this may appear as an advantageous strategy, transient defects in spindle geometry may be even more threatening to a cell population or organism than permanent spindle defects. Indeed, transient spindle geometry defects cause high rates of chromosome mis-segregation and aneuploidy. In this review, we summarize our current knowledge on two specific types of transient spindle geometry defects (transient multipolarity and incomplete spindle pole separation) and describe how these mechanisms cause chromosome mis-segregation and aneuploidy. Finally, we discuss how these transient spindle defects may specifically contribute to the chromosomal instability observed in cancer cells.
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New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Sikirzhytski, Vitali
Magidson, Valentin
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New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Magidson, Valentin
Steinman, Jonathan B.
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Rockefeller Univ, New York, NY 10021 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Steinman, Jonathan B.
He, Jie
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New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
He, Jie
Le Berre, Mael
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Inst Curie, F-75248 Paris, FranceNew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Le Berre, Mael
Tikhonenko, Irina
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New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Tikhonenko, Irina
Ault, Jeffrey G.
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New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Ault, Jeffrey G.
McEwen, Bruce F.
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New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
McEwen, Bruce F.
Chen, James K.
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Stanford Sch Med, Stanford, CA 94305 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Chen, James K.
Sui, Haixin
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New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Sui, Haixin
Pie, Matthieu
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Inst Curie, F-75248 Paris, FranceNew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Pie, Matthieu
Kapoor, Tarun M.
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Rockefeller Univ, New York, NY 10021 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Kapoor, Tarun M.
Khodjakov, Alexey
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机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Rensselaer Polytech Inst, Troy, NY 12180 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
机构:
Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Inst Curie, CNRS, UMR 144, F-75005 Paris, FranceUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Costa, Judite
Fu, Chuanhai
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h-index: 0
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Univ Hong Kong, Dept Biochem, Pokfulam, Hong Kong, Peoples R ChinaUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Fu, Chuanhai
Khare, V. Mohini
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Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USAUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Khare, V. Mohini
Tran, Phong T.
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h-index: 0
机构:
Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Inst Curie, CNRS, UMR 144, F-75005 Paris, FranceUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Sikirzhytski, Vitali
Magidson, Valentin
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h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Magidson, Valentin
Steinman, Jonathan B.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, New York, NY 10021 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Steinman, Jonathan B.
He, Jie
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h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
He, Jie
Le Berre, Mael
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h-index: 0
机构:
Inst Curie, F-75248 Paris, FranceNew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Le Berre, Mael
Tikhonenko, Irina
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h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Tikhonenko, Irina
Ault, Jeffrey G.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Ault, Jeffrey G.
McEwen, Bruce F.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
McEwen, Bruce F.
Chen, James K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Sch Med, Stanford, CA 94305 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Chen, James K.
Sui, Haixin
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Sui, Haixin
Pie, Matthieu
论文数: 0引用数: 0
h-index: 0
机构:
Inst Curie, F-75248 Paris, FranceNew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Pie, Matthieu
Kapoor, Tarun M.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, New York, NY 10021 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Kapoor, Tarun M.
Khodjakov, Alexey
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
Rensselaer Polytech Inst, Troy, NY 12180 USANew York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA
机构:
Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Inst Curie, CNRS, UMR 144, F-75005 Paris, FranceUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Costa, Judite
Fu, Chuanhai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Biochem, Pokfulam, Hong Kong, Peoples R ChinaUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Fu, Chuanhai
Khare, V. Mohini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USAUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Khare, V. Mohini
Tran, Phong T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
Inst Curie, CNRS, UMR 144, F-75005 Paris, FranceUniv Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA