Cholic acid-functionalized nanoparticles of star-shaped PLGA-vitamin E TPGS copolymer for docetaxel delivery to cervical cancer

被引：263
作者：
Zeng, Xiaowei [1 ,2 ,3 ]
Tao, Wei [1 ,2 ,3 ]
Mei, Lin [1 ,2 ,3 ]
Huang, Laigiang [1 ,2 ,3 ]
Tan, Chunyan [1 ,2 ,3 ]
Feng, Si-Shen [1 ,2 ,3 ,4 ]
机构：
[1] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Shenzhen Grad Sch, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Peoples R China
[3] Tsinghua Univ, Shenzhen Grad Sch, Div Life & Hlth Sci, Shenzhen 518055, Peoples R China
[4] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore
来源：
BIOMATERIALS | 2013年 / 34卷 / 25期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Anticancer drugs; Cancer nanotechnology; Controlled release; Drug delivery; Molecular biomaterials; Nanomedicine; DRUG-DELIVERY; MULTIDRUG-RESISTANCE; LOADED NANOPARTICLES; CONTROLLED-RELEASE; BLOCK-COPOLYMERS; CELLULAR UPTAKE; ORAL DELIVERY; BREAST-CANCER; SUCCINATE; POLYMERS;
D O I：
10.1016/j.biomaterials.2013.04.052
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We developed a system of nanoparticles (NPs) of cholic acid functionalized, star-shaped block copolymer consisting of PLGA and vitamin E TPGS for sustained and controlled delivery of docetaxel for treatment of cervical cancer, which demonstrated superior in vitro and in vivo performance in comparison with the drug-loaded PLGA NPs and the linear PLGA-b-TPGS copolymer NPs. The star-shaped block copolymer CA-PLGA-b-TPGS of three branch arms was synthesized through the core-first approach and characterized by H-1 NMR, GPC and TGA. The drug- or coumarin 6-loaded NPs were prepared by a modified nanoprecipitation technique and then characterized in terms of size and size distribution, surface morphology and surface charge, drug encapsulation efficiency, in vitro release profile and physical state of the encapsulated drug. The CA-PLGA-b-TPGS NPs were found to have the highest cellular uptake efficiency, the highest antitumor efficacy compared with PLGA-b-TPGS NPs and PLGA NPs. The results suggest that such a star-shaped copolymer CA-PLGA-b-TPGS could be used as a new molecular biomaterial for drug delivery of high efficiency. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6058 / 6067
页数：10
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