Targeting splicing abnormalities in cancer

被引：59

作者：

Agrawal, Anant A. ^{[1
]}

Yu, Lihua ^{[1
]}

Smith, Peter G. ^{[1
]}

Buonamici, Silvia ^{[1
]}

机构：

[1] H3 Biomed Inc, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2018年 / 48卷

关键词：

EVERY; 3; WEEKS; PHASE-I; MUTATIONS; SPLICEOSOME; INHIBITOR; SULFONAMIDE; MODULATION; E7070; GENOME; TRANSCRIPTOME;

D O I：

10.1016/j.gde.2017.10.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently splicing has been recognized as a key pathway in cancer. Although aberrant splicing has been shown to be a consequence of mutations or the abnormal expression of splicing factors (trans-effect changes) or mutations in the splicing sequences (cis-effect mutations), the connections between aberrant splicing and cancer initiation or progression are still not well understood. Here we review the mutational landscape of splicing factors in cancer and associated splicing consequences, along with the most important examples of the therapeutic approaches targeting the spliceosome currently being investigated in oncology.

引用

页码：67 / 74

页数：8

共 72 条

[1] Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage [J].

Alsafadi, Samar ;

Houy, Alexandre ;

Battistella, Aude ;

Popova, Tatiana ;

Wassef, Michel ;

Henry, Emilie ;

Tirode, Franck ;

Constantinou, Angelos ;

Piperno-Neumann, Sophie ;

Roman-Roman, Sergio ;

Dutertre, Martin ;

Stern, Marc-Henri .

NATURE COMMUNICATIONS, 2016, 7

[2] The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation [J].

Anczukow, Olga ;

Rosenberg, Avi Z. ;

Akerman, Martin ;

Das, Shipra ;

Zhan, Lixing ;

Karni, Rotem ;

Muthuswamy, Senthil K. ;

Krainer, Adrian R. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (02) :220-228

[3]

[Anonymous], 2017, ELIFE

[4]

[Anonymous], ELIFE

[5]

[Anonymous], AM SOC HEMATOLOGY

[6]

[Anonymous], WILEY INTERDISCIP RE

[7]

[Anonymous], MELANOMA RES

[8] Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing [J].

Araki, Shinsuke ;

Dairiki, Ryo ;

Nakayama, Yusuke ;

Murai, Aiko ;

Miyashita, Risa ;

Iwatani, Misa ;

Nomura, Toshiyuki ;

Nakanishi, Osamu .

PLOS ONE, 2015, 10 (01)

[9] Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes [J].

Biankin, Andrew V. ;

Waddell, Nicola ;

Kassahn, Karin S. ;

Gingras, Marie-Claude ;

Muthuswamy, Lakshmi B. ;

Johns, Amber L. ;

Miller, David K. ;

Wilson, Peter J. ;

Patch, Ann-Marie ;

Wu, Jianmin ;

Chang, David K. ;

Cowley, Mark J. ;

Gardiner, Brooke B. ;

Song, Sarah ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Manning, Suzanne ;

Wani, Shivangi ;

Gongora, Milena ;

Pajic, Marina ;

Scarlett, Christopher J. ;

Gill, Anthony J. ;

Pinho, Andreia V. ;

Rooman, Ilse ;

Anderson, Matthew ;

Holmes, Oliver ;

Leonard, Conrad ;

Taylor, Darrin ;

Wood, Scott ;

Xu, Qinying ;

Nones, Katia ;

Fink, J. Lynn ;

Christ, Angelika ;

Bruxner, Tim ;

Cloonan, Nicole ;

Kolle, Gabriel ;

Newell, Felicity ;

Pinese, Mark ;

Mead, R. Scott ;

Humphris, Jeremy L. ;

Kaplan, Warren ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chou, Angela ;

Chin, Venessa T. ;

Chantrill, Lorraine A. .

NATURE, 2012, 491 (7424) :399-405

[10] The spliceosome as a target of novel antitumour drugs [J].

Bonnal, Sophie ;

Vigevani, Luisa ;

Valcarcel, Juan .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (11) :847-859

← 1 2 3 4 5 6 7 8 →