Genistein and its Fatty Acid Esters as New In vitro Antitumor Compounds

被引：2

作者：

Citu, Cosmin ^{[1
]}

Danciu, Corina ^{[2
]}

Pinzaru, Iulia ^{[2
]}

Ghiulai, Roxana ^{[2
]}

Vlaia, Lavinia ^{[2
]}

Vlaia, Vicentiu ^{[2
]}

Borcan, Florin ^{[2
]}

Dumitru, Catalin ^{[1
]}

Pavel, Ioana Zinuca ^{[2
]}

Sas, Ioan ^{[1
]}

Bernad, Elena ^{[1
]}

机构：

[1] Victor Babes Univ Med & Pharm Timisoara, Fac Med, Timisoara 300041, Romania

[2] Victor Babes Univ Med & Pharm Timisoara, Fac Pharm, Timisoara 300041, Romania

来源：

REVISTA DE CHIMIE | 2015年 / 66卷 / 08期

关键词：

genistein; esters; antiproliferative activity; A431; A375; CANCER CELL-LINES; DERIVATIVES; MECHANISMS; ISOFLAVONE; APOPTOSIS; ARREST; CYCLE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This present study describes the biological activity of genistein and genistein derivatives with ester structure on two tumor cell lines, A431 (skin epidermoid carcinoma) and A375 (human melanoma). Genistein esters were synthesized following the pathway of chemical esterification which involved solvent medium, triethylamine and fatty acid chloride. Esterification of genistein leads to increased hydrophobicity in order to have a better absorption while the compounds cross the membrane barrier.

引用

页码：1100 / 1104

页数：5

共 18 条

[1] High concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species [J].

Chen, Wei ;

Lin, Ying Cai ;

Ma, Xian Yong ;

Jiang, Zong Yong ;

Lan, Si Ping .

FOOD AND CHEMICAL TOXICOLOGY, 2014, 67 :72-79

[2] Preliminary studies on induction of apoptosis by genistein on HepG2 cell line [J].

Chodon, Dechen ;

Ramamurty, Nalini ;

Sakthisekaran, D. .

TOXICOLOGY IN VITRO, 2007, 21 (05) :887-891

[3] International Union of Pharmacology.: LXIV.: Estrogen receptors [J].

Dahlman-Wright, Karin ;

Cavailles, Vincent ;

Fuqua, Suzanne A. ;

Jordan, V. Craig ;

Katzenellenbogen, John A. ;

Korach, Kenneth S. ;

Maggi, Adriana ;

Muramatsu, Masami ;

Parker, Malcolm G. ;

Gustafsson, Jan-Ake .

PHARMACOLOGICAL REVIEWS, 2006, 58 (04) :773-781

[4]

Danciu C, 2013, NAT PROD COMMUN, V8, P343

[5] Changes in the anti-inflammatory activity of soy isoflavonoid genistein versus genistein incorporated in two types of cyclodextrin derivatives [J].

Danciu, CorinaTiulea ;

Soica, Codruta ;

Csanyi, Erzsebet ;

Ambrus, Rita ;

Feflea, Stefana ;

Peev, Camelia ;

Dehelean, Cristina .

CHEMISTRY CENTRAL JOURNAL, 2012, 6

[6]

Davis S R., 1998, Integr Med, V1, P27, DOI DOI 10.1016/S1096-2190(98)00019-5

[7] RETRACTED: Genistein Enhances the Effect of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Inhibits Nuclear Factor Kappa B in Nonsmall Cell Lung Cancer Cell Lines (Retracted article. See vol. 122, pg. 3248, 2016) [J].

Gadgeel, Shirish M. ;

Ali, Shadan ;

Philip, Philip A. ;

Wozniak, Antoinette ;

Sarkar, Fazlul H. .

CANCER, 2009, 115 (10) :2165-2176

[8]

GHEORGHEOSU D., 2014, UV RAD SKIN PATH WOR

[9]

Grynkiewicz G., 2000, Herba Polonica, V46, P151

[10] Interactions of cyclic nucleotide-gated channel subunits and protein tyrosine kinase probed with genistein [J].

Molokanova, E ;

Savchenko, A ;

Kramer, RH .

JOURNAL OF GENERAL PHYSIOLOGY, 2000, 115 (06) :685-696

← 1 2 →