Preventive effect of Imperatorin on acute lung injury induced by lipopolysaccharide in mice

被引：31
作者：
Sun, Jingjing [1 ]
Chi, Gefu [2 ]
Soromou, Lanan Wassy [1 ]
Chen, Na [1 ]
Guan, Mingfeng [1 ]
Wu, Qianchao [1 ]
Wang, Dacheng [1 ]
Li, Hongyu [1 ]
机构：
[1] Jilin Univ, Coll Anim Sci & Vet Med, Changchun 130062, Peoples R China
[2] Inner Mongolia Natl Univ, Coll Anim Sci & Technol, Tongliao 028042, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2012年 / 14卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Imperatorin; Acute lung injury; Lipopolysaccharide; Mice; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; KINASE PATHWAYS; RECEPTOR; MACROPHAGES; CELLS;
D O I：
10.1016/j.intimp.2012.07.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Imperatorin, a linear furanocoumarin, has many pharmacological effects such as antibacterial, anti-inflammatory and antiviral effects. The purpose of this study was to investigate the effect of Imperatorin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. BALB/c mice were pretreated with Imperatorin 1 h before LPS challenge. We found that the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) in the bronchoalveolar lavage fluid (BALF) were decreased significantly, and the level of interleukin-10 (IL-10) was up-regulated 8 h after Imperatorin treatment. Pretreatment with Imperatorin (15 or 30 mg/kg) decreased lung wet-to-dry weight (W/D) ratio, the number of inflammatory cells and myeloperoxidase (MPO) activities. Additionally, Imperatorin attenuated lung histopathological changes and significantly inhibited the phosphorylation of I kappa B, JNK, ERK and p38/MAPK. These findings demonstrate that Imperatorin protects against LPS-induced ALI in mice. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：369 / 374
页数：6
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