The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

被引：1092

作者：

Torchia, J

Rose, DW

Inostroza, J

Kamei, Y

Westin, S

Glass, CK

Rosenfeld, MG

机构：

[1] UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, LA JOLLA, CA 92093 USA

[2] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA

[3] UNIV CALIF SAN DIEGO, WHITTIER DIABET PROGRAM, LA JOLLA, CA 92093 USA

[4] UNIV CALIF SAN DIEGO, CELLULAR & MOL MED SCH, LA JOLLA, CA 92093 USA

来源：

NATURE | 1997年 / 387卷 / 6634期

关键词：

D O I：

10.1038/42652

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CEP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors, p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that ape required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways.

引用

页码：677 / 684

页数：8

共 46 条

[1] ACTIVATION OF CAMP AND MITOGEN RESPONSIVE GENES RELIES ON A COMMON NUCLEAR FACTOR [J].