The current role of neoadjuvant chemotherapy in the management of cervical carcinoma

被引：67
作者：
Gonzalez-Martin, Antonio [1 ,2 ]
Gonzalez-Cortijo, Lucia [2 ]
Carballo, Natalia [3 ]
Garcia, Juan F. [4 ]
Lapuente, Fernando [5 ]
Rojo, Alejandro [4 ]
Chiva, Luis M. [5 ]
机构：
[1] Hosp Ramon & Cajal, Med Oncol Serv, E-28034 Madrid, Spain
[2] MD Anderson Int Espana, Dept Med Oncol, Madrid, Spain
[3] MD Anderson Int Espana, Dept Radiat Oncol, Madrid, Spain
[4] MD Anderson Int Espana, Dept Pathol, Madrid, Spain
[5] MD Anderson Int Espana, Dept Gynecol Oncol, Madrid, Spain
来源：
GYNECOLOGIC ONCOLOGY | 2008年 / 110卷 / 03期
关键词：
neoadjuvant chemotherapy; cervical carcinoma; chemotherapy; meta-analysis;
D O I：
10.1016/j.ygyno.2008.05.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of neoadjuvant chemotherapy (NACT) in cervical cancer has been a matter of investigation over the last 20 years. A systematic review and meta-analysis of individual patient data (IPD) demonstrated that NACT followed by surgery is superior to radiotherapy alone in terms of overall survival. However, in spite of the results of the meta-analysis, NACT has not been adopted as the new standard of care. In the present paper, we review the reasons why NACT is still considered an investigational approach in cervical cancer. (C) 2008 Elsevier Inc. All rights reserved.
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收藏
页码：S36 / S40
页数：5
相关论文
共 19 条
  • [1] Long-term survival following neoadjuvant chemotherapy and radical surgery in locally advanced cervical cancer
    Benedetti-Panici, P
    Greggi, S
    Scambia, G
    Amoroso, M
    Salerno, MG
    Maneschi, F
    Cutillo, G
    Paratore, MP
    Scorpiglione, N
    Mancuso, S
    [J]. EUROPEAN JOURNAL OF CANCER, 1998, 34 (03) : 341 - 346
  • [2] Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: Results from the Italian Multicenter Randomized study
    Benedetti-Panici, P
    Greggi, S
    Colombo, A
    Amoroso, M
    Smaniotto, D
    Giannarelli, D
    Amunni, G
    Raspagliesi, F
    Zola, P
    Mangioni, C
    Landoni, F
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (01) : 179 - 188
  • [3] Neoadjuvant chemotherapy for locally advanced cervical cancer:: a systematic review and meta-analysis of individual patient data from 21 randomised trials
    Benedetti-Panici, P
    Bermudez, A
    Blake, P
    Cárdenas, J
    Chang, TC
    Chiara, S
    Di Paola, G
    Floquet, A
    Guthrie, D
    Kigawa, J
    Kumar, L
    Leborgne, F
    Lodge, N
    Poole, C
    Sardi, J
    Souhami, L
    Sundfor, K
    Symonds, P
    Tattersall, M
    Greggi, S
    Guthrie, D
    Parker, V
    Parmar, MKB
    Sardi, J
    Stewart, LA
    Tierney, JF
    [J]. EUROPEAN JOURNAL OF CANCER, 2003, 39 (17) : 2470 - 2486
  • [4] Randomized trial of neoadjuvant chemotherapy comparing paclitaxel, ifosfamide, and cisplatin with ifosfamide and cisplatin followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: The SNAP01 (studio neo-adjuvante portio) Italian collaborative study
    Buda, A
    Fossati, R
    Colombo, N
    Fei, F
    Floriani, I
    Alletti, DG
    Katsaros, D
    Landoni, F
    Lissoni, A
    Malzoni, C
    Sartori, E
    Scollo, P
    Torri, V
    Zola, P
    Mangioni, C
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (18) : 4137 - 4145
  • [5] Neoadjuvant treatment of locally advanced carcinoma of the uterine cervix with epirubicin, paclitaxel and cisplatin
    D'Agostino, G
    Distefano, M
    Greggi, S
    Salerno, M
    Ferrandina, G
    Poerio, A
    Mancuso, S
    Scambia, G
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2002, 49 (03) : 256 - 260
  • [6] Cisplatin and vinorelbine as neoadjuvant chemotherapy in locally advanced cervical cancer: A Phase II study
    di Vagno, G
    Cormio, G
    Pignata, S
    Scambia, G
    Di Stefano, MG
    Tambaro, R
    Trerotoli, P
    Serio, G
    Garganese, G
    Selvaggi, L
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2003, 13 (03) : 308 - 312
  • [7] A phase II study of multimodality treatment for locally advanced cervical cancer:: neoadjuvant carboplatin and paclitaxel followed by radical hysterectomy and adjuvant cisplatin chemoradiation
    Dueñas-Gonzalez, A
    López-Graniel, C
    González-Enciso, A
    Cetina, L
    Rivera, L
    Mariscal, I
    Montalvo, G
    Gómez, E
    de la Garza, J
    Chanona, G
    Mohar, A
    [J]. ANNALS OF ONCOLOGY, 2003, 14 (08) : 1278 - 1284
  • [8] Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase II studies
    Duenas-Gonzalez, A
    Lopez-Graniel, C
    Gonzalez-Enciso, A
    Mohar, A
    Rivera, L
    Mota, A
    Guadarrama, R
    Chanona, G
    de la Garza, J
    [J]. ANNALS OF ONCOLOGY, 2002, 13 (08) : 1212 - 1219
  • [9] Treatment of ("bulky") stage IB cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: A phase III trial of the gynecologic oncology group
    Eddy, Gary L.
    Bundy, Brian N.
    Creasman, William T.
    Spirtos, Nick M.
    Mannel, Robert S.
    Hannigan, Edward
    O'Connor, Dennis
    [J]. GYNECOLOGIC ONCOLOGY, 2007, 106 (02) : 362 - 369
  • [10] Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis
    Green, JA
    Kirwan, JM
    Tierney, JF
    Symonds, P
    Fresco, L
    Collingwood, M
    Williams, CJ
    [J]. LANCET, 2001, 358 (9284) : 781 - 786
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