Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017

被引：145

作者：

Giri, Veda N. ^{[1
]}

Knudsen, Karen E. ^{[1
]}

Kelly, William K. ^{[1
]}

Abida, Wassim ^{[7
]}

Andriole, Gerald L. ^{[9
]}

Bangma, Chris H. ^{[10
]}

Bekelman, Justin E. ^{[2
]}

Benson, Mitchell C. ^{[8
]}

Blanco, Amie ^{[11
]}

Burnett, Arthur ^{[15
]}

Catalona, William J. ^{[17
]}

Cooney, Kathleen A. ^{[19
]}

Cooperberg, Matthew ^{[11
]}

Crawford, David E. ^{[20
]}

Den, Robert B. ^{[1
]}

Dicker, Adam P. ^{[1
]}

Eggener, Scott ^{[18
]}

Fleshner, Neil ^{[23
]}

Freedman, Matthew L. ^{[24
,25
]}

Hamdy, Freddie C. ^{[26
]}

Hoffman-Censits, Jean ^{[1
]}

Hurwitz, Mark D. ^{[1
]}

Hyatt, Colette ^{[1
]}

Isaacs, William B. ^{[15
]}

Kane, Christopher J. ^{[12
]}

Kantoff, Philip ^{[7
]}

Karnes, R. Jeffrey ^{[27
]}

Karsh, Lawrence I. ^{[21
]}

Klein, Eric A. ^{[28
]}

Lin, Daniel W. ^{[30
]}

Loughlin, Kevin R. ^{[24
,25
]}

Lu-Yao, Grace ^{[1
]}

Malkowicz, S. Bruce ^{[3
]}

Mann, Mark J. ^{[1
]}

Mark, James R. ^{[1
]}

Mccue, Peter A. ^{[1
]}

Miner, Martin M. ^{[31
]}

Morgan, Todd ^{[32
]}

Moul, Judd W. ^{[34
]}

Myers, Ronald E. ^{[1
]}

Nielsen, Sarah M. ^{[18
]}

Obeid, Elias ^{[4
]}

Pavlovich, Christian P. ^{[15
]}

Peiper, Stephen C. ^{[1
]}

Penson, David F. ^{[35
]}

Petrylak, Daniel ^{[36
]}

Pettaway, Curtis A. ^{[37
]}

Pilarski, Robert ^{[29
]}

Pinto, Peter A. ^{[16
]}

Poage, Wendy ^{[22
]}

机构：

[1] Jefferson Sidney Kimmel Canc Ctr, Philadelphia, PA USA

[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Philadelphia, PA 19104 USA

[4] Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA

[5] Fdn Breast & Prostate Hlth, Philadelphia, PA USA

[6] Abington Hosp Jefferson Hlth, Hanjani Inst Gynecol Oncol, Abington, PA USA

[7] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[8] Columbia Univ, New York, NY USA

[9] Washington Univ, Sch Med, St Louis, MO USA

[10] Erasmus MC, Rotterdam, Netherlands

[11] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[12] Univ Calif San Diego, San Diego, CA 92103 USA

[13] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[14] Prostate Canc Fdn, Santa Monica, CA USA

[15] Johns Hopkins Med Inst, Baltimore, MD 21205 USA

[16] NCI, Bethesda, MD 20892 USA

[17] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[18] Univ Chicago, Chicago, IL 60637 USA

[19] Univ Utah, Sch Med, Salt Lake City, UT USA

[20] Univ Colorado, Aurora, CO USA

[21] Urol Ctr Colorado, Denver, CO USA

[22] Prostate Condit Educ Council, Elizabeth, CO USA

[23] Univ Toronto, Princess Margaret Canc Ctr, Toronto, ON, Canada

[24] Dana Farber Canc Inst, Boston, MA 02115 USA

[25] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[26] Univ Oxford, Oxford, England

[27] Mayo Clin, Rochester, MN USA

[28] Cleveland Clin, Cleveland, OH 44106 USA

[29] Ohio State Univ, Columbus, OH 43210 USA

[30] Univ Washington, Seattle, WA 98195 USA

[31] Brown Univ, Providence, RI 02912 USA

[32] Univ Michigan, Ann Arbor, MI 48109 USA

[33] Mid Michigan Hlth Ctr, Jackson, MI USA

[34] Duke Univ, Duke Canc Inst, Durham, NC USA

[35] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[36] Yale Univ, New Haven, CT USA

[37] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[38] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA

[39] Tulane Univ, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USA

[40] Atlantic Urol Clin, Carolina Urol Res Ctr, Myrtle Beach, SC USA

[41] Amer Canc Soc, Atlanta, GA 30329 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2018年 / 36卷 / 04期

关键词：

MISMATCH REPAIR DEFICIENCY; HOXB13 G84E MUTATION; GERMLINE MUTATIONS; BRCA2; MUTATION; BREAST; CARRIERS; MEN; CONSORTIUM; ACCURACY; SURVIVAL;

D O I：

10.1200/JCO.2017.74.1173

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATMto inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA-a clinically heterogeneous disease. (C) 2017 by American Society of Clinical Oncology

引用

页码：414 / +

页数：23

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