Self-assembly, drug-delivery behavior, and cytotoxicity evaluation of amphiphilic chitosan-graft-poly (1,4-dioxan-2-one) copolymers

被引：14

作者：

Wang, Xiu-Li ^{[1
]}

Zhai, Yan-Li ^{[1
]}

Tang, Dao-Lu ^{[1
]}

Liu, Gui-Ying ^{[1
]}

Wang, Yu-Zhong ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Ctr Degradable & Flame Retardant Polymer Mat ERCE, State Key Lab Polymer Mat Engn, Chengdu 610064, Peoples R China

来源：

JOURNAL OF POLYMER RESEARCH | 2012年 / 19卷 / 09期

基金：

美国国家科学基金会;

关键词：

Chitosan; Poly(1,4-dioxan-2-one); Micelle; Drug release; Cytotoxicity; RELEASE BEHAVIOR; BLOCK-COPOLYMERS; MICELLES; POLYCAPROLACTONE; NANOPARTICLES; CRYSTALLINE; NANOSPHERES; ACID); PLA;

D O I：

10.1007/s10965-012-9946-x

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A series of biocompatible and amphiphilic chitosangraft- poly(1,4-dioxan-2-one) (CS-g-PPDO) copolymers were synthesized using a low molecular weight chitosan (M-n - 5x10(3) Da). The resulting copolymers could self-assemble into micelles in aqueous medium. The critical micelle concentration, size, and morphology of the micelles were characterized by fluorescence spectra, dynamic light scattering (DLS), atomic force microscopy (AFM), and transmission electron microscopy (TEM). These polymer micelles were used as drug carriers for nimodipine (a model drug). It was found that nimodipine was released from the micelles for periods as long as 100 h without a burst release occurring. In addition, the MTT assay showed that the CS-g-PPDO copolymers exhibited low cytotoxicity and good biocompatibility with L929 cells, highlighting the potential of these copolymers as drug-delivery carriers.

引用

页数：9

共 40 条

[1] Copolymerization of poly(vinyl alcohol)-graft-poly(1,4-dioxan-2-one) with designed molecular structure by a solid-state polymerization method [J].