The benefits of the multi-target approach in drug design and discovery

被引：128
|
作者：
Espinoza-Fonseca, LM [1 ]
机构：
[1] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 04期
关键词：
drug design; promiscuous drug; cancer; Alzheimer's disease;
D O I：
10.1016/j.bmc.2005.09.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Promiscuous binding has been considered to be a problem in the design and development of new drugs against a given disease. However, promiscuity in Molecular recognition is not all bad news, and scientists are currently taking advantage of the emerging 'promiscuous binding' or 'multi-target approach' in medicinal chemistry. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：896 / 897
页数：2
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