Retinol and α-tocopherol in pregnancy: Establishment of reference intervals and associations with CBC

被引:13
|
作者
Liu, Jingrui [1 ]
Zhan, Sien [1 ]
Jia, Yan [1 ]
Li, Youran [1 ]
Liu, Ying [1 ]
Dong, Ying [1 ]
Tang, Guodong [1 ,2 ]
Li, Lin [3 ]
Zhai, Yanhong [1 ]
Cao, Zheng [1 ]
机构
[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Lab Med, 251 Yaojiayuan Rd, Beijing 100026, Peoples R China
[2] Beijing Haidian Maternal & Child Hlth Hosp, Prenatal Diag Ctr, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Cent Lab, Beijing, Peoples R China
来源
MATERNAL AND CHILD NUTRITION | 2020年 / 16卷 / 03期
关键词
anaemia; Hoffmann method; inflammation; LC-MS; MS; maternal nutrition; nutritional status; pregnancy; quantitative methods; reference interval; retinol; alpha-tocopherol; VITAMIN-A; PLATELET-AGGREGATION; SERUM; CAROTENOIDS; SUPPLEMENTATION; INFLAMMATION; DEFICIENCY; CHILDREN; ANEMIA; GAMMA;
D O I
10.1111/mcn.12975
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Profound physiological changes during pregnancy may affect the requirement of retinol and tocopherol, which are essential micronutrients for the maintenance of maternal health and foetal development. However, the current reference intervals (RIs) of retinol and tocopherol are based on non-pregnant population. In the present study, a liquid chromatography-tandem mass spectrometry quantitation method for serum retinol and alpha-tocopherol was established and validated. In addition, we established trimester-specific RIs of retinol and alpha-tocopherol using the data from paired screening test for 31,301 outpatients who participated in the prenatal vitamins A/E evaluation program at our hospital using the Hoffmann method, which is a simple indirect RI estimation method that does not require the recruitment of healthy subjects. Further, to explore the associations between the levels of retinol and alpha-tocopherol and the parameters of complete blood count (CBC), the results of retinol, alpha-tocopherol, and CBC of 1,977 pregnant outpatients in the third trimester were analysed. The testing interval between the levels of vitamins and CBC was no more than 7 days. Although no significant changes were noticed in the levels of retinol, the alpha-tocopherol levels continuously increased with normal physiological changes throughout pregnancy. Lower retinol levels were associated with the higher incidence of anaemia, whereas higher levels of retinol and lower levels of alpha-tocopherol were associated with higher platelet count.
引用
收藏
页数:9
相关论文
共 50 条
  • [1] Establishment of reference intervals of complete blood count for twin pregnancy
    Zeng, Yifan
    Li, Lei
    Mao, Man
    Liang, Xinghua
    Chen, Min
    Xia, Yong
    He, Wenyin
    BMC PREGNANCY AND CHILDBIRTH, 2021, 21 (01)
  • [2] Serum prolactin levels across pregnancy and the establishment of reference intervals
    Hu, Yun
    Ding, Yiling
    Yang, Mengyuan
    Xiang, Zhongyuan
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2018, 56 (05) : 838 - 842
  • [3] Establishment of reference intervals of complete blood count for twin pregnancy
    Yifan Zeng
    Lei Li
    Man Mao
    Xinghua Liang
    Min Chen
    Yong Xia
    Wenyin He
    BMC Pregnancy and Childbirth, 21
  • [4] Establishment of reference intervals for thyroid function tests during pregnancy
    Amari, K. Mourabit
    Bondaz, L.
    Girouard, J.
    Gagnon, C.
    Weisnagel, J.
    Forest, J-C
    Giguere, Y.
    CLINICAL BIOCHEMISTRY, 2012, 45 (13-14) : 1114 - 1114
  • [5] The establishment of tocopherol reference intervals for Hungarian adult population using a validated HPLC method
    Veres, Gabor
    Szpisjak, Laszlo
    Bajtai, Attila
    Siska, Andrea
    Klivenyi, Peter
    Ilisz, Istvan
    Foldesi, Imre
    Vecsei, Laszlo
    Zadori, Denes
    BIOMEDICAL CHROMATOGRAPHY, 2017, 31 (09)
  • [6] Calculation of reference intervals for the concentrations of α-tocopherol and retinol in serum using indirect data-mining procedures
    Rigo-Bonnin, Raul
    Aliart-Fernandez, Irene
    Escalante-Vilanova, Anna
    Brunet, Merce
    Parra-Robert, Marina
    Morales-Ruiz, Manuel
    CLINICA CHIMICA ACTA, 2024, 561
  • [7] Associations of Serum Retinol, α-Tocopherol, and γ-Tocopherol with Biomarkers among Healthy Japanese Men
    Zou, Yu
    Wang, Da-Hong
    Sakano, Noriko
    Sato, Yoshie
    Iwanaga, Suketaka
    Taketa, Kazuhisa
    Kubo, Masayuki
    Takemoto, Kei
    Masatomi, Chie
    Inoue, Kiyomi
    Ogino, Keiki
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2014, 11 (02) : 1647 - 1660
  • [8] Glycated albumin in pregnancy: reference intervals establishment and its predictive value in adverse pregnancy outcomes
    Dong, Ying
    Zhai, Yanhong
    Wang, Jing
    Chen, Yi
    Xie, Xin
    Zhang, Chunhong
    Liu, Jingrui
    Lu, Yifan
    Tang, Guodong
    Han, Lican
    Li, Lin
    Cao, Zheng
    BMC PREGNANCY AND CHILDBIRTH, 2020, 20 (01)
  • [9] Glycated albumin in pregnancy: reference intervals establishment and its predictive value in adverse pregnancy outcomes
    Ying Dong
    Yanhong Zhai
    Jing Wang
    Yi Chen
    Xin Xie
    Chunhong Zhang
    Jingrui Liu
    Yifan Lu
    Guodong Tang
    Lican Han
    Lin Li
    Zheng Cao
    BMC Pregnancy and Childbirth, 20
  • [10] Establishment of reference intervals in Indian population
    Tester F. Ashavaid
    Seema P. Todur
    Alpa J. Dherai
    Indian Journal of Clinical Biochemistry, 2005, 20 (2) : 110 - 118