Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

被引：553

作者：

Folmes, Clifford D. L. ^{[1
]}

Dzeja, Petras P. ^{[1
]}

Nelson, Timothy J. ^{[1
]}

Terzic, Andre ^{[1
]}

机构：

[1] Mayo Clin, Ctr Regenerat Med, Rochester, MN 55905 USA

来源：

CELL STEM CELL | 2012年 / 11卷 / 05期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

ENERGY-METABOLISM; MITOCHONDRIAL BIOGENESIS; HEMATOPOIETIC PROGENITORS; ANTIOXIDANT ENZYMES; PLURIPOTENCY; ACETYLATION; PROLIFERATION; REJUVENATION; QUIESCENCE; GLYCOLYSIS;

D O I：

10.1016/j.stem.2012.10.002

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support, new evidence implicates nutrient-responsive metabolites as mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. Stem cell metabolism also offers a potential target for controlling tissue homeostasis and regeneration in aging and disease. In this Perspective, we cover recent progress establishing an emerging relationship between stem cell metabolism and cell fate control.

引用

页码：596 / 606

页数：11

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