Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

被引：553
作者：
Folmes, Clifford D. L. [1 ]
Dzeja, Petras P. [1 ]
Nelson, Timothy J. [1 ]
Terzic, Andre [1 ]
机构：
[1] Mayo Clin, Ctr Regenerat Med, Rochester, MN 55905 USA
来源：
CELL STEM CELL | 2012年 / 11卷 / 05期
基金：
加拿大健康研究院; 美国国家卫生研究院;
关键词：
ENERGY-METABOLISM; MITOCHONDRIAL BIOGENESIS; HEMATOPOIETIC PROGENITORS; ANTIOXIDANT ENZYMES; PLURIPOTENCY; ACETYLATION; PROLIFERATION; REJUVENATION; QUIESCENCE; GLYCOLYSIS;
D O I：
10.1016/j.stem.2012.10.002
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support, new evidence implicates nutrient-responsive metabolites as mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. Stem cell metabolism also offers a potential target for controlling tissue homeostasis and regeneration in aging and disease. In this Perspective, we cover recent progress establishing an emerging relationship between stem cell metabolism and cell fate control.
引用
收藏
页码：596 / 606
页数：11
相关论文
共 98 条
[1]   Metabolic differentiation in the embryonic retina [J].
Agathocleous, Michalis ;
Love, Nicola K. ;
Randlett, Owen ;
Harris, Julia J. ;
Liu, Jinyue ;
Murray, Andrew J. ;
Harris, William A. .
NATURE CELL BIOLOGY, 2012, 14 (08) :859-U180
[2]   Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice [J].
Ahlqvist, Kati J. ;
Hamalainen, Riikka H. ;
Yatsuga, Shuichi ;
Uutela, Marko ;
Terzioglu, Mugen ;
Gotz, Alexandra ;
Forsstrom, Saara ;
Salven, Petri ;
Angers-Loustau, Alexandre ;
Kopra, Outi H. ;
Tyynismaa, Henna ;
Larsson, Nils-Goran ;
Wartiovaara, Kirmo ;
Prolla, Tomas ;
Trifunovic, Aleksandra ;
Suomalainen, Anu .
CELL METABOLISM, 2012, 15 (01) :100-109
[3]   TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].
Bensaad, Karim ;
Tsuruta, Atsushi ;
Selak, Mary A. ;
Calvo Vidal, M. Nieves ;
Nakano, Katsunori ;
Bartrons, Ramon ;
Gottlieb, Eyal ;
Vousden, Karen H. .
CELL, 2006, 126 (01) :107-120
[4]   Evidence for Cardiomyocyte Renewal in Humans [J].
Bergmann, Olaf ;
Bhardwaj, Ratan D. ;
Bernard, Samuel ;
Zdunek, Sofia ;
Barnabe-Heider, Fanie ;
Walsh, Stuart ;
Zupicich, Joel ;
Alkass, Kanar ;
Buchholz, Bruce A. ;
Druid, Henrik ;
Jovinge, Stefan ;
Frisen, Jonas .
SCIENCE, 2009, 324 (5923) :98-102
[5]   Carbon metabolism-mediated myogenic differentiation [J].
Bracha, Abigail L. ;
Ramanathan, Arvind ;
Huang, Sui ;
Ingber, Donald E. ;
Schreiber, Stuart L. .
NATURE CHEMICAL BIOLOGY, 2010, 6 (03) :202-204
[6]   Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs [J].
Brookes, Emily ;
de Santiago, Ines ;
Hebenstreit, Daniel ;
Morris, Kelly J. ;
Carroll, Tom ;
Xie, Sheila Q. ;
Stock, Julie K. ;
Heidemann, Martin ;
Eick, Dirk ;
Nozaki, Naohito ;
Kimura, Hiroshi ;
Ragoussis, Jiannis ;
Teichmann, Sarah A. ;
Pombo, Ana .
CELL STEM CELL, 2012, 10 (02) :157-170
[7]   Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes [J].
Cai, Ling ;
Sutter, Benjamin M. ;
Li, Bing ;
Tu, Benjamin P. .
MOLECULAR CELL, 2011, 42 (04) :426-437
[8]   Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function [J].
Cerletti, Massimiliano ;
Jang, Young C. ;
Finley, Lydia W. S. ;
Haigis, Marcia C. ;
Wagers, Amy J. .
CELL STEM CELL, 2012, 10 (05) :515-519
[9]   Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells [J].
Chen, Chien-Tsun ;
Shih, Yu-Ru V. ;
Kuo, Tom K. ;
Lee, Oscar K. ;
Wei, Yau-Huei .
STEM CELLS, 2008, 26 (04) :960-968
[10]   TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species [J].
Chen, Chong ;
Liu, Yu ;
Liu, Runhua ;
Ikenoue, Tsuneo ;
Guan, Kun-Liang ;
Liu, Yang ;
Zheng, Pan .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (10) :2397-2408
12345678910