Morus alba L. Stem Extract Attenuates Pain and Articular Cartilage Damage in the Anterior Cruciate Ligament Transection-Induced Rat Model of Osteoarthritis

被引：9

作者：

Khunakornvichaya, Arada ^{[1
]}

Lekmeechai, Sujinna ^{[2
]}

Phi Phuong Pham ^{[2
]}

Himakoun, Wanwisa ^{[3
]}

Pitaksuteepong, Tasana ^{[4
]}

Morales, Noppawan Phumala ^{[2
]}

Hemstapat, Warinkarn ^{[2
]}

机构：

[1] Mahidol Univ, Multidisciplinary Unit, Grad Program Toxicol, Bangkok, Thailand

[2] Mahidol Univ, Dept Pharmacol, Fac Sci, Rama 6 Rd, Bangkok 10400, Thailand

[3] Thammasat Univ, Fac Med, Dept Pathol & Forens Med, Pathum Thani, Thailand

[4] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol, Phitsanulok, Thailand

来源：

PHARMACOLOGY | 2016年 / 98卷 / 5-6期

关键词：

Osteoarthritis; Morus alba L; Anti-nociceptive effect; Anterior cruciate ligament transection; Cartilage protective effect; NITRIC-OXIDE; OXIDATIVE STRESS; LEAF EXTRACT; GLUCOSAMINE; MECHANISMS; PATHOPHYSIOLOGY; OXYRESVERATROL; INFLAMMATION; POLYPHENOLS; CYTOKINES;

D O I：

10.1159/000447973

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: This study was designed to investigate the anti-nociceptive effect of Morus alba stem extract as well as its cartilage protective effect in the anterior cruciate ligament transection (ACLT)-induced rat model of osteoarthritis (OA). Methods: The anti-nociceptive effect of this plant extract was determined by measuring hind limb weight bearing, while the severity of cartilage damage to the knee joints was evaluated using the modified Mankin grading system. Results: Oral administration of M. alba stem extract (56 and 560 mg/kg) significantly attenuated joint pain as indicated by a significant (p < 0.05) increase in the values of percent weight borne on the operated hind limb for the OA-induced groups that received M. alba stem extract at 56 and 560 mg/kg when compared to those of the vehicle-treated OA-induced group. In addition, a significant improvement in the Mankin score was also observed in rats treated with 560 mg/kg M. alba stem extract, which was in agreement with its pain-relieving effect. Conclusion: The results showed that M. alba stem extract exhibited an anti-nociceptive effect as well as cartilage protection in the ACLT-induced rat model of OA, supporting its potential use as a therapeutic treatment for OA. (C) 2016 S. Karger AG, Basel

引用

页码：209 / 216

页数：8

共 38 条

[1] Inflammation in osteoarthritis [J].

Goldring, Mary B. ;

Otero, Miguel .

CURRENT OPINION IN RHEUMATOLOGY, 2011, 23 (05) :471-478

[2] Nitric oxide in inflammation and pain associated with osteoarthritis [J].

Abramson, Steven B. .

ARTHRITIS RESEARCH & THERAPY, 2008, 10 (Suppl 2)

[3] Reactive oxygen species and superoxide dismutases: Role in joint diseases [J].

Afonso, Valery ;

Champy, Rornuald ;

Mitrovic, Dragoslav ;

Collin, Pascal ;

Lomri, Abderrahim .

JOINT BONE SPINE, 2007, 74 (04) :324-329

[4] COX-2, NO, and cartilage damage and repair. [J].

Amin A.R. ;

Dave M. ;

Attur M. ;

Abramson S.B. .

Current Rheumatology Reports, 2000, 2 (6) :447-453

[5] Acetaminophen or NSAIDs for the treatment of osteoarthritis [J].

Bannwarth, B .

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2006, 20 (01) :117-129

[6] New advances in musculoskeletal pain [J].

Bove, Susan E. ;

Flatters, Sarah J. L. ;

Inglis, Julia J. ;

Mantyh, Patrick W. .

BRAIN RESEARCH REVIEWS, 2009, 60 (01) :187-201

[7] A quantitative approach to measure joint pain in experimental osteoarthritis - evidence of a role for nitric oxide [J].

Castro, R. R. ;

Cunha, F. Q. ;

Silva, F. S., Jr. ;

Rocha, F. A. C. .

OSTEOARTHRITIS AND CARTILAGE, 2006, 14 (08) :769-776

[8] Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark [J].

Chang, Lee-Wen ;

Juang, Lih-Jeng ;

Wang, Bor-Sen ;

Wang, Mei-Ying ;

Tai, Huo-Mu ;

Hung, Wei-Jing ;

Chen, Yun-Ju ;

Huang, Ming-Hsing .

FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (04) :785-790

[9] Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines, in RAW264.7 macrophages [J].

Choi, EM ;

Hwang, JK .

FITOTERAPIA, 2005, 76 (7-8) :608-613

[10] In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. [J].

Chung, KO ;

Kim, BY ;

Lee, MH ;

Kim, YR ;

Chung, HY ;

Park, JH ;

Moon, JO .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2003, 55 (12) :1695-1700

← 1 2 3 4 →