Regulatory long non-coding RNA and its functions

被引：86

作者：

Huang, Yong ^{[2
]}

Liu, Ning ^{[2
]}

Wang, Jian Ping ^{[2
]}

Wang, Yu Qin ^{[2
]}

Yu, Xue Li ^{[2
]}

Bin Wang, Zhan ^{[2
]}

Cheng, Xiang Chao ^{[2
]}

Zou, Quan ^{[1
]}

机构：

[1] Xiamen Univ, Sch Informat Sci & Technol, Xiamen 361005, Peoples R China

[2] He Nan Univ Sci & Technol, Anim Sci & Technol Coll, Luoyang City 471003, Henan Province, Peoples R China

来源：

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY | 2012年 / 68卷 / 04期

关键词：

lncRNAs; Gene expression; Epigenetic; Disease; Cancer; NATURAL ANTISENSE TRANSCRIPT; GENOME-WIDE IDENTIFICATION; MESSENGER-RNA; H19; GENE; CHROMATIN; EXPRESSION; APOPTOSIS; BINDING; REPRESSOR; ENHANCER;

D O I：

10.1007/s13105-012-0166-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of large numbers of long non-coding RNAs (lncRNAs) has been driven by genome-wide transcriptional analyses. Compared to small ncRNAs, lncRNAs have been shown to harbor biological activities, but the functions of the great majority of lncRNAs are not known. There is growing evidence that lncRNAs can regulate gene expression at epigenetic, transcription, and post-transcription levels and widely take part in various physiological and pathological processes, such as participating in cell development, immunity, oncogenesis, clinical disease processes, etc. Here, the current research efforts on the function of lncRNA in recent years were summarized.

引用

页码：611 / 618

页数：8

共 67 条

[1] Non-coding RNAs revealed during identification of genes involved in chicken immune responses [J].

Ahanda, Marie-Laure Endale ;

Ruby, Thomas ;

Wittzell, Hayenkan ;

Bed'Hom, Bertrand ;

Chausse, Anne-Marie ;

Morin, Veronique ;

Oudin, Anne ;

Chevalier, Catherine ;

Young, John R. ;

Zoorob, Rima .

IMMUNOGENETICS, 2009, 61 (01) :55-70

[2] Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression [J].

Annilo, Tarmo ;

Kepp, Katrin ;

Laan, Maris .

BMC MOLECULAR BIOLOGY, 2009, 10

[3] The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race [J].

Aravin, Alexei A. ;

Hannon, Gregory J. ;

Brennecke, Julius .

SCIENCE, 2007, 318 (5851) :761-764

[4] The product of the imprinted H19 gene is an oncofetal RNA [J].

Ariel, I ;

Ayesh, S ;

Perlman, EJ ;

Pizov, G ;

Tanos, V ;

Schneider, T ;

Erdmann, VA ;

Podeh, D ;

Komitowski, D ;

Quasem, AS ;

deGroot, N ;

Hochberg, A .

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 1997, 50 (01) :34-44

[5] A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition [J].

Beltran, Manuel ;

Puig, Isabel ;

Pena, Cristina ;

Miguel Garcia, Jose ;

Belen Alvarez, Ana ;

Pena, Raul ;

Bonilla, Felix ;

Garcia de Herreros, Antonio .

GENES & DEVELOPMENT, 2008, 22 (06) :756-769

[6] THE PRODUCT OF THE H19 GENE MAY FUNCTION AS AN RNA [J].

BRANNAN, CI ;

DEES, EC ;

INGRAM, RS ;

TILGHMAN, SM .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (01) :28-36

[7] A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME [J].

BROWN, CJ ;

BALLABIO, A ;

RUPERT, JL ;

LAFRENIERE, RG ;

GROMPE, M ;

TONLORENZI, R ;

WILLARD, HF .

NATURE, 1991, 349 (6304) :38-44

[8] Enhancers: The abundance and function of regulatory sequences beyond promoters [J].

Bulger, Michael ;

Groudine, Mark .

DEVELOPMENTAL BIOLOGY, 2010, 339 (02) :250-257

[9] A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced [J].

Chaumeil, Julie ;

Le Baccon, Patricia ;

Wutz, Anton ;

Heard, Edith .

GENES & DEVELOPMENT, 2006, 20 (16) :2223-2237

[10] Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility [J].

Chung, Suyoun ;

Nakagawa, Hidewaki ;

Uemura, Motohide ;

Piao, Lianhua ;

Ashikawa, Kyota ;

Hosono, Naoya ;

Takata, Ryo ;

Akamatsu, Shusuke ;

Kawaguchi, Takahisa ;

Morizono, Takashi ;

Tsunoda, Tatsuhiko ;

Daigo, Yataro ;

Matsuda, Koichi ;

Kamatani, Naoyuki ;

Nakamura, Yusuke ;

Kubo, Michiaki .

CANCER SCIENCE, 2011, 102 (01) :245-252

← 1 2 3 4 5 6 7 →