Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives

被引：34

作者：

Sondhi, Sham M. ^{[1
]}

Kumar, Sandeep ^{[1
]}

Kumar, Nikhil ^{[2
]}

Roy, Partha ^{[2
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, UK, India

[2] Indian Inst Technol Roorkee, Dept Biotechnol, Roorkee 247667, UK, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期

关键词：

Pyrazole derivatives; Oxadiazole derivatives; Anticancer; Anti-inflammatory activity; MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL EVALUATION; ANTIMALARIAL ACTIVITY; 1,3,4-OXADIAZOLE DERIVATIVES; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; COX-2; INHIBITORS; COLON-CANCER; AGENTS; ANALOGS;

D O I：

10.1007/s00044-011-9850-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrazole derivatives IIa-l have been synthesized by condensation of chalcones Ia-f with hydrazine hydrate and phenyl hydrazine under microwave irradiation in good yields. Oxadiazole derivatives IVa-f have been synthesized by condensation of N'-hydroxypicolinamidine, N'-hydroxy isonicotinamidine, N'-hydroxypyrazine-2-carboxamidine with 2,5 dimethoxybenzaldehyde and 3-methoxy-4-hydroxy benzaldehyde, respectively. Structures assigned to IIa-l and IVa-f are fully supported by correct spectral and analytical data. All compounds (IIa-l & IVa-f) have been screened for anti-inflammatory and anticancer activities. Compounds IIj, IIk, and IVb exhibited good anti-inflammatory activity, while, IIa, c, j, and IVd showed better anticancer activity against four and three cancer cell lines, respectively.

引用

页码：3043 / 3052

页数：10

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