Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives

被引：34
作者：
Sondhi, Sham M. [1 ]
Kumar, Sandeep [1 ]
Kumar, Nikhil [2 ]
Roy, Partha [2 ]
机构：
[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, UK, India
[2] Indian Inst Technol Roorkee, Dept Biotechnol, Roorkee 247667, UK, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期
关键词：
Pyrazole derivatives; Oxadiazole derivatives; Anticancer; Anti-inflammatory activity; MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL EVALUATION; ANTIMALARIAL ACTIVITY; 1,3,4-OXADIAZOLE DERIVATIVES; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; COX-2; INHIBITORS; COLON-CANCER; AGENTS; ANALOGS;
D O I：
10.1007/s00044-011-9850-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrazole derivatives IIa-l have been synthesized by condensation of chalcones Ia-f with hydrazine hydrate and phenyl hydrazine under microwave irradiation in good yields. Oxadiazole derivatives IVa-f have been synthesized by condensation of N'-hydroxypicolinamidine, N'-hydroxy isonicotinamidine, N'-hydroxypyrazine-2-carboxamidine with 2,5 dimethoxybenzaldehyde and 3-methoxy-4-hydroxy benzaldehyde, respectively. Structures assigned to IIa-l and IVa-f are fully supported by correct spectral and analytical data. All compounds (IIa-l & IVa-f) have been screened for anti-inflammatory and anticancer activities. Compounds IIj, IIk, and IVb exhibited good anti-inflammatory activity, while, IIa, c, j, and IVd showed better anticancer activity against four and three cancer cell lines, respectively.
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页码：3043 / 3052
页数：10
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