Combined determination of the chemical composition and of health effects of secondary organic aerosols: The POLYSOA project

被引：92

作者：

Baltensperger, Urs ^{[1
]}

Dommen, Josef ^{[1
]}

Alfarra, Rami ^{[1
]}

Duplissy, Jonathan ^{[1
]}

Gaeggeler, Kathrin ^{[1
]}

Metzger, Axel ^{[1
]}

Facchini, Maria Cristina ^{[2
]}

Decesari, Stefano ^{[2
]}

Finessi, Emanuela ^{[2
]}

Reinnig, Christopher ^{[3
]}

Schott, Mathias ^{[3
]}

Warnke, Joerg ^{[3
]}

Hoffmann, Thorsten ^{[3
]}

Klatzer, Barbara ^{[4
]}

Puxbaum, Hans ^{[4
]}

Geiser, Marianne ^{[5
]}

Savi, Melanie ^{[5
]}

Lang, Doris ^{[5
]}

Kalberer, Markus ^{[6
]}

Geiser, Thomas ^{[7
]}

机构：

[1] Paul Scherrer Inst, Lab Atmospher Chem, CH-5232 Villigen, Switzerland

[2] CNR, Inst Atmospher Sci & Climate ISAC, Bologna, Italy

[3] Johannes Gutenberg Univ Mainz, Mainz, Germany

[4] Vienna Univ Technol, Inst Chem Technol & Analyt, A-1040 Vienna, Austria

[5] Univ Bern, Inst Anat, CH-3012 Bern, Switzerland

[6] Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Zurich, Switzerland

[7] Univ Hosp, Div Pulm Med, CH-3010 Bern, Switzerland

来源：

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY | 2008年 / 21卷 / 01期

基金：

英国自然环境研究理事会;

关键词：

chemical composition; health effects; secondary organic aerosols;

D O I：

10.1089/jamp.2007.0655

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Epidemiological studies show a clear link between increased mortality and enhanced. concentrations of ambient aerosols. The chemical and physical properties of aerosol particles causing these health effects remain unclear. A major fraction of the ambient aerosol particle mass is composed of secondary organic aerosol (SOA). Recent studies showed that. a significant amount of SOA consists of high molecular weight compounds (oligomers), which are chemically not well characterized. Within the POLYSOA project a large variety of state-ofthe-art analytical chemical methods were used to characterize the chemical composition of SOA particles with emphasis on the. oligomeric mass fraction. Mass spectrometric results showed that SOA oligomers are highly oxidized compounds and that hydroperoxides are formed, which is consistent with NMR results. This high molecular weight fraction accounts for up to 23% of the total organic carbon in SOA particles. These well-characterized SOA particles were deposited on three lung cell culture systems (microdissected respiratory epithelia from porcine tracheae, the human bronchial epithelial cell line BEAS-213, and porcine lung surface macrophages obtained by bronchoalveolar lavage) in a newly constructed particle'deposition chamber with the goal to eventually identify particle components that are responsible for cell responses leading to adverse health effects. In addition, monolayers of the alveolar epithelial cell line A549 were used in an alveolar epithelial repair model. The lung cells were examined for morphological, biochemical, and physiological changes after exposure to SOA. Analyses of the lung cells after exposure to SOA are ongoing. First data give evidence for a moderate increase of necrotic cell death as measured by lactate dehydrogenase release and for effects on the alveolar epithelial wound repair mainly due to alterations of cell spreading and cell migration at the edge of the wound. Thus, these first results indicate that SOA, in concentrations comparable to environmental concentrations, may induce distinct effects in lung cells.

引用

页码：145 / 154

页数：10

共 27 条

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