Annulation of functionalized hexadienones as an efficient regioselective approach to N-aryl-2-(trifluoromethyl)-4-pyridinamines

被引：16

作者：

Cocco, MT ^{[1
]}

Congiu, C ^{[1
]}

Onnis, V ^{[1
]}

机构：

[1] Univ Cagliari, Dipartimento Farm Chim Tecnol, I-09124 Cagliari, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 23期

关键词：

dienones; annulation; pyridines; regioselection;

D O I：

10.1016/S0040-4039(99)00758-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Readily accessible fluorinated N-arylenaminones 3 were reacted with N,N-dimethylformamide dimethylacetal to produce functionalized hexadienones 4. Ring closure of 4 with ammonium acetate afforded selectively N-aryl-2-(trifluoromethyl)-4-pyridinamines 5 in good to excellent yields. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4407 / 4410

页数：4

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