Movement within and movement beyond Synaptotagmin-mediated vesicle fusion during chemotaxis

被引：2

作者：

Colvin, Richard A. ^{[1
]}

Luster, Andrew D. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA

来源：

CELL ADHESION & MIGRATION | 2011年 / 5卷 / 01期

关键词：

chemotaxis; synaptotagmin; vesicle trafficking; lysosome; uropod; rab; LYSOSOMAL-ENZYME RELEASE; CELL-MIGRATION; LEADING LAMELLA; FIBROBLASTS; LOCOMOTION; CULTURE; EXOCYTOSIS; RECEPTORS; SECRETION; MEMBRANE;

D O I：

10.4161/cam.5.1.13197

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Leukocyte chemotaxis plays an essential role in generating and delivering immune responses and is a critical component of inflammation. In order to identify novel genes and pathways important for regulating chemotaxis, we performed an RNAi-based screen and identified several genes involved with vesicle movement and fusion as mediators of chemotaxis. Our recently published data(1) show that during chemotaxis vesicle trafficking proteins are required for lysosome fusion, uropod release and efficient directed cell migration.

引用

页码：56 / 58

页数：3

共 19 条

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