Telomere length, oxidative stress, and antioxidant status in elderly men in Zutphen and Crete

被引:27
作者
de Vos-Houben, Joyce M. J. [2 ]
Ottenheim, Nathaly Rius [1 ]
Kafatos, Anthony [3 ,4 ]
Buijsse, Brian [5 ]
Hageman, Geja J. [2 ]
Kromhout, Daan [6 ]
Giltay, Erik J. [1 ]
机构
[1] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands
[2] Maastricht Univ, Med Ctr, Dept Toxicol, NUTRIM Sch Nutr Toxicol & Metab, Maastricht, Netherlands
[3] Univ Crete, Sch Med, Dept Prevent Med, Iraklion, Crete, Greece
[4] Univ Crete, Sch Med, Nutr Clin, Iraklion, Crete, Greece
[5] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany
[6] Wageningen Univ, Div Human Nutr, Wageningen, Netherlands
关键词
Telomere length; Elderly men; Oxidative stress; Antioxidants; OBSTRUCTIVE PULMONARY-DISEASE; CORONARY-HEART-DISEASE; PERIPHERAL-BLOOD CELLS; CARDIOVASCULAR-DISEASE; CANCER; ALBUMIN; PREVENTION; LEUKOCYTES; MORTALITY; SURVIVAL;
D O I
10.1016/j.mad.2012.04.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of telomeres, the nucleoprotein structures at the ends of chromosomes. We compared leukocyte telomere length (LTL) in elderly men from Northern and Southern Europe and investigated the possible relationship between LTL and indicators of oxidative stress and antioxidant status. We examined 143 elderly Dutch men (mean age 83.9 years) and 109 Greek elderly men (mean age 84.6 years) and found that the Greek men had significantly longer telomeres (geometric mean 4.95 kbp, 95% confidence interval (Cl): 4.71-5.23 kbp) compared to the men from the Netherlands (4.76 kbp, 95% Cl: 4.55-4.98 kbp; P=0.001). Age was inversely associated with LTL (beta=-0.10, P=0.31 in Cretan men and beta=-0.19, P=0.02 in Dutch men). In all men LTL was not related to indicators of oxidative stress and plasma antioxidants. However, the endogenous antioxidants serum albumin (beta=0.18, P=0.007) and uric acid (beta=0.13, P=0.045) were positively associated with LTL. The age-adjusted difference between Crete and Zutphen was reduced by 25% after adjustment for serum albumin and uric acid. We conclude that Greek elderly men have significantly longer LTL compared to Dutch counterparts. The endogenous antioxidants albumin and uric acid were positively associated with longer telomeres. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:373 / 377
页数:5
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