Glycine receptors and brain development

被引：80

作者：

Avila, Ariel ^{[1
,2
,3
]}

Laurent Nguyen ^{[2
,3
,4
]}

Rigo, Jean-Michel ^{[1
]}

机构：

[1] Hasselt Univ, BIOMED Res Inst, Diepenbeek, Belgium

[2] Univ Liege, CHU Sart Tilman, Grp Interdisciplinaire Genoprote Appl Neurosci, Liege, Belgium

[3] Univ Liege, CHU Sart Tilman, Grp Interdisciplinaire Genoprote Appl Res, Liege, Belgium

[4] Univ Liege, CHU Sart Tilman, Walloon Excellence Life Sci & Biotechnol, Liege, Belgium

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2013年 / 7卷

关键词：

glycine receptors; GlyRs; glycine; brain development; cortex; hippocampus; interneurons; migration; MINIATURE POSTSYNAPTIC CURRENTS; CORTICAL INTERNEURON MIGRATION; GRAMICIDIN PERFORATED-PATCH; CAJAL-RETZIUS CELLS; SYNAPTIC-TRANSMISSION; KCC2; EXPRESSION; GRANULE CELLS; CHROMOSOMAL LOCALIZATION; GLUTAMATERGIC SYNAPSES; TRANSMITTER RELEASE;

D O I：

10.3389/fncel.2013.00184

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult. However, these receptors are also expressed in upper regions of the central nervous system, where they participate in different processes including synaptic neurotransmission. Moreover, GlyRs are present since early stages of brain development and might influence this process. Here, we discuss the current state of the art regarding GlyRs during embryonic and postnatal brain development in light of recent findings about the cellular and molecular mechanisms that control brain development.

引用

页数：11

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