Glycine receptors and brain development

被引:80
作者
Avila, Ariel [1 ,2 ,3 ]
Laurent Nguyen [2 ,3 ,4 ]
Rigo, Jean-Michel [1 ]
机构
[1] Hasselt Univ, BIOMED Res Inst, Diepenbeek, Belgium
[2] Univ Liege, CHU Sart Tilman, Grp Interdisciplinaire Genoprote Appl Neurosci, Liege, Belgium
[3] Univ Liege, CHU Sart Tilman, Grp Interdisciplinaire Genoprote Appl Res, Liege, Belgium
[4] Univ Liege, CHU Sart Tilman, Walloon Excellence Life Sci & Biotechnol, Liege, Belgium
关键词
glycine receptors; GlyRs; glycine; brain development; cortex; hippocampus; interneurons; migration; MINIATURE POSTSYNAPTIC CURRENTS; CORTICAL INTERNEURON MIGRATION; GRAMICIDIN PERFORATED-PATCH; CAJAL-RETZIUS CELLS; SYNAPTIC-TRANSMISSION; KCC2; EXPRESSION; GRANULE CELLS; CHROMOSOMAL LOCALIZATION; GLUTAMATERGIC SYNAPSES; TRANSMITTER RELEASE;
D O I
10.3389/fncel.2013.00184
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult. However, these receptors are also expressed in upper regions of the central nervous system, where they participate in different processes including synaptic neurotransmission. Moreover, GlyRs are present since early stages of brain development and might influence this process. Here, we discuss the current state of the art regarding GlyRs during embryonic and postnatal brain development in light of recent findings about the cellular and molecular mechanisms that control brain development.
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页数:11
相关论文
共 136 条
[1]   NMDA RECEPTOR-MEDIATED CURRENTS ARE PROMINENT IN THE THALAMOCORTICAL SYNAPTIC RESPONSE BEFORE MATURATION OF INHIBITION [J].
AGMON, A ;
ODOWD, DK .
JOURNAL OF NEUROPHYSIOLOGY, 1992, 68 (01) :345-349
[2]   Age-related changes of glycine receptor at the rat hippocampus: from the embryo to the adult [J].
Aroeira, Rita I. ;
Ribeiro, Joaquim A. ;
Sebastiao, Ana M. ;
Valente, Claudia A. .
JOURNAL OF NEUROCHEMISTRY, 2011, 118 (03) :339-353
[3]   Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration [J].
Avila, Ariel ;
Vidal, Pia M. ;
Dear, T. Neil ;
Harvey, Robert J. ;
Rigo, Jean-Michel ;
Nguyen, Laurent .
CELL REPORTS, 2013, 4 (04) :738-750
[4]   Glycine-activated currents are changed by coincident membrane depolarization in developing rat auditory brainstem neurones [J].
Backus, KH ;
Deitmer, JW ;
Friauf, E .
JOURNAL OF PHYSIOLOGY-LONDON, 1998, 507 (03) :783-794
[5]   Interneurons set the tune of developing networks [J].
Ben-Ari, Y ;
Khalilov, I ;
Represa, A ;
Gozlan, H .
TRENDS IN NEUROSCIENCES, 2004, 27 (07) :422-427
[6]   Excitatory actions of GABA during development: The nature of the nurture [J].
Ben-Ari, Y .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (09) :728-739
[7]   GABA: A pioneer transmitter that excites immature neurons and generates primitive oscillations [J].
Ben-Ari, Yehezkel ;
Gaiarsa, Jean-Luc ;
Tyzio, Roman ;
Khazipov, Rustem .
PHYSIOLOGICAL REVIEWS, 2007, 87 (04) :1215-1284
[8]   GIANT SYNAPTIC POTENTIALS IN IMMATURE RAT CA3 HIPPOCAMPAL-NEURONS [J].
BENARI, Y ;
CHERUBINI, E ;
CORRADETTI, R ;
GAIARSA, JL .
JOURNAL OF PHYSIOLOGY-LONDON, 1989, 416 :303-325
[9]   Prenatal and postnatal contents of amino acid neurotransmitters in mouse parietal cortex [J].
Benítez-Diaz, P ;
Miranda-Contreras, L ;
Mendoza-Briceño, RV ;
Peña-Contreras, Z ;
Palacios-Prü, E .
DEVELOPMENTAL NEUROSCIENCE, 2003, 25 (05) :366-374
[10]   KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner [J].
Bortone, Dante ;
Polleux, Franck .
NEURON, 2009, 62 (01) :53-71