TMP21 in Alzheimer's Disease: Molecular Mechanisms and a Potential Target

被引：8
作者：
Qiu, Kaixin [1 ,2 ,3 ]
Zhang, Xiaojie [4 ,5 ,6 ]
Wang, Shuai [2 ,3 ]
Li, Chunyan [1 ,2 ,3 ]
Wang, Xin [2 ,3 ]
Li, Xuezhi [2 ,3 ]
Wu, Yili [2 ,3 ]
机构：
[1] Shandong Univ, Cheeloo Coll Med, Jinan, Shandong, Peoples R China
[2] Jining Med Univ, Shandong Collaborat Innovat Ctr Diag Treatment &, Inst Mental Hlth, Jining, Peoples R China
[3] Jining Med Univ, Sch Mental Hlth, Shandong Key Lab Behav Med, Jining, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China
[5] Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China
[6] Natl Technol Inst Mental Disorders, Changsha, Hunan, Peoples R China
来源：
FRONTIERS IN CELLULAR NEUROSCIENCE | 2019年 / 13卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; TMP21; A beta; Tau phosphorylation; neuronal loss; A-BETA PRODUCTION; P24; FAMILY; AMYLOID-BETA; ENDOPLASMIC-RETICULUM; ANCHORED PROTEINS; TRANSPORT; TRAFFICKING; COMPONENT; APOPTOSIS; SECRETASE;
D O I：
10.3389/fncel.2019.00328
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is the most common form of dementia in the elderly, which is characterized by progressive cognitive impairment. Neuritic plaques, neurofibrillary tangles and neuronal loss are the major neuropathological hallmarks in AD brains. TMP21 is a key molecule for protein trafficking in cells. Growing evidence indicates that TMP21 is dysregulated in AD, which plays a pivotal role in neuritic plaque formation. Therefore, we aim to review the dysregulation of TMP21 in AD, the role of TMP21 in neuritic plaque formation and underlying mechanisms. Moreover, the potential role of TMP21 in neurofibrillary tangle formation, synaptic impairment and neuronal loss is discussed. It will provide an outlook into the potential of regulating TMP21 as a therapeutic approach for AD treatment.
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页数：8
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