Process intensification and optimization for hydroxyapatite nanoparticles production

被引：42

作者：

Castro, Filipa ^{[1
]}

Kuhn, Simon ^{[2
]}

Jensen, Klavs ^{[3
]}

Ferreira, Antonio ^{[1
]}

Rocha, Fernando ^{[4
]}

Vicente, Antonio ^{[1
]}

Teixeira, Jose Antonio ^{[1
]}

机构：

[1] Univ Minho, Ctr Biol Engn, IBB, P-4710057 Braga, Portugal

[2] UCL, Dept Chem Engn, London WC1 7JE, England

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[4] Univ Porto, Fac Engn, LEPAE Lab Proc Environm & Energy Engn, P-4200465 Oporto, Portugal

来源：

CHEMICAL ENGINEERING SCIENCE | 2013年 / 100卷

关键词：

Hydroxyapatite; Microreactor; Precipitation; Laminar flow; Segmented flow; Aggregation; CARBONATED HYDROXYAPATITE; CALCIUM HYDROXIDE; PRECIPITATION; CRYSTALLIZATION; KINETICS; DISSOLUTION;

D O I：

10.1016/j.ces.2013.01.002

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Precipitation processes are widely used in industry for the production of particulate solids. Efficient mixing of the reagents is of major importance for the chemical and physical nature of the synthesized particles. Recently, microreactors have been studied to overcome homogeneity problems found when using stirred tank batch reactors. The present work investigated an ultrasonic tubular microreactor for the continuous-flow precipitation of hydroxyapatite (HAp), both in single-phase flow (SPF) and in gas-liquid flow (GLF). HAp nanoparticles were yielded for both configurations under near-physiological conditions of pH and temperature. The as-prepared particles, especially those that were prepared under GLF, show improved characteristics compared to commercial powder or powder obtained in a stirred tank batch reactor. Primary particles are smaller, particle shape is more homogeneous, and the aggregation degree of the particles is lower. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：352 / 359

页数：8

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