Rho GTPases in neurodegeneration diseases

被引：38

作者：

DeGeer, Jonathan ^{[1
]}

Lamarche-Vane, Nathalie ^{[1
]}

机构：

[1] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 0C7, Canada

来源：

EXPERIMENTAL CELL RESEARCH | 2013年 / 319卷 / 15期

关键词：

Rho GTPases; Neurodegeneration; Neurite outgrowth; RhoGEFs; RhoGAPs; Nerve injury; NUCLEOTIDE EXCHANGE FACTOR; ACTIVATED PROTEIN-KINASE; ACTIN STRESS FIBERS; FACTOR-KAPPA-B; ALZHEIMERS-DISEASE; BINDING-PROTEIN; NOGO RECEPTOR; LIM-KINASE; AXONAL DEGENERATION; PRECURSOR PROTEIN;

D O I：

10.1016/j.yexcr.2013.06.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rho GTPases are molecular switches that modulate multiple intracellular signaling processes by means of various effector proteins. As a result, Rho GTPase activities are tightly spatiotemporally regulated in order to ensure homeostasis within the cell. Though the roles of Rho GTPases during neural development have been well documented, their participation during neurodegeneration has been far less characterized. Herein we discuss our current knowledge of the role and function of Rho GTPases and regulators during neurodegeneration, and highlight their potential as targets for therapeutic intervention in common neurodegenerative disorders. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：2384 / 2394

页数：11

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