p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas

被引:0
|
作者
Benhattar, J [1 ]
Cerottini, JP [1 ]
Saraga, E [1 ]
Metthez, G [1 ]
Givel, JC [1 ]
机构
[1] CHU VAUDOIS,DEPT SURG,CH-1011 LAUSANNE,SWITZERLAND
关键词
D O I
10.1002/(SICI)1097-0215(19960621)69:3<190::AID-IJC7>3.0.CO;2-V
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Although intrahepatic infusion therapy with 5-fluorouracil for unresectable colorectal liver metastases may lead to improved overall survival for some patients, it is not clear why a response is not observed in others. Gene alterations in oncogenes or tumor-suppressor genes are critical events in tumor formation, and some of them could play a role in the process of drug resistance. The tumor-suppressor gene p53, which is known to trigger cell arrest or apoptosis in response to DNA damage, is found to be mutated in a wide range of human tumors, The aim of this work is to establish whether a relationship is found between p53 mutations and survival in patients undergoing adjuvant chemotherapy for advanced Dukes' D colorectal cancers. Seventeen tumors from patients treated with 5-fluorouracil regimen via intrahepatic infusion for unresectable colorectal hepatic metastasis were considered, p53 mutations from tumor DNA were detected, after amplification by PCR of exons 5 to 8, by non-radioactive single-strand conformation polymorphism and direct DNA sequencing. Patients with mutated p53 colorectal tumors had short survival, whereas prolonged survival was associated with the presence of wild-type p53 (p = 0.019), Our data suggest that mutated p53 colorectal tumors had a weak response, or even no response, to chemotherapeutic treatment, Routine assessment of p53 status would be helpful in selecting patients with only wild-type p53 gene who have a predictably better response to chemotherapy. (C) 1996 Wiley-Liss, Inc.
引用
收藏
页码:190 / 192
页数:3
相关论文
共 50 条
  • [31] P53 MUTATIONS AND P53 PROTEIN ACCUMULATION AND COMPARTMENTALIZATION IN LARGE-BOWEL CARCINOMAS
    BOSARI, S
    VIALE, G
    RONCALLI, M
    GRAZIANI, D
    BORSANI, G
    LEE, AKC
    COGGI, G
    LABORATORY INVESTIGATION, 1995, 72 (01) : A58 - A58
  • [32] p53 status and response to chemotherapy
    Bénard, J
    Ahomadégbé, JC
    BULLETIN DU CANCER, 2002, 89 (12) : 1007 - 1010
  • [33] Correlation of p53 oncoprotein expression with chemotherapy response in small cell lung carcinomas
    Rodríguez-Salas, N
    Palacios, J
    Moreno, G
    de Castro, J
    González-Barón, M
    Gamallo, C
    LUNG CANCER, 2001, 34 (01) : 67 - 74
  • [34] Correlation of p53 oncoprotein expression with chemotherapy response in small cell lung carcinomas
    Sales, NR
    Amat, CG
    Palacios, J
    de las Heras, B
    Gonzalez-Barón, M
    EUROPEAN JOURNAL OF CANCER, 1999, 35 : S61 - S61
  • [35] Association of p53 mutations with metastatic prostate cancer
    Eastham, JA
    Stapleton, AMF
    Gousse, AE
    Timme, TL
    Yang, G
    Slawin, KM
    Wheeler, TM
    Scardino, PT
    Thompson, TC
    CLINICAL CANCER RESEARCH, 1995, 1 (10) : 1111 - 1118
  • [36] Overexpression and mutations of p53 in metastatic malignant melanomas
    Hartmann, A
    Blaszyk, H
    Cunningham, JS
    McGovern, RM
    Schroeder, JS
    Helander, SD
    Pittelkow, MR
    Sommer, SS
    Kovach, JS
    INTERNATIONAL JOURNAL OF CANCER, 1996, 67 (03) : 313 - 317
  • [37] p53 status as potential predictor for response to chemotherapy in locally advanced gastric cancer
    Cascinu, S
    DelFerro, E
    Staccioli, P
    Ligi, M
    Graziano, F
    Carnevali, A
    Polizzi, V
    Muretto, P
    Catalano, G
    EUROPEAN JOURNAL OF CANCER, 1997, 33 : 1248 - 1248
  • [38] P53 POINT MUTATIONS IN PRIMARY HUMAN GASTRIC CARCINOMAS
    YOKOZAKI, H
    KUNIYASU, H
    KITADAI, Y
    NISHIMURA, K
    TODO, H
    AYHAN, A
    YASUI, W
    ITO, H
    TAHARA, E
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1992, 119 (02) : 67 - 70
  • [39] P53 MUTATIONS IN HEPATOCELLULAR CARCINOMAS (HCCS) FROM KOREA
    PARK, YM
    YOON, SK
    KIM, BS
    TABOR, E
    HEPATOLOGY, 1994, 20 (04) : A384 - A384
  • [40] Molecular and immunohistochemical analysis of p53 mutations in breast carcinomas
    Zachariou, Christianna
    Malamou-Mitsi, Vassiliki
    Skyrlas, Angelos
    Agnantis, Niki
    VIRCHOWS ARCHIV, 2007, 451 (02) : 567 - 567