Toll-like receptor 9 SNPs are susceptible to the development and progression of membranous glomerulonephritis: 27 years follow-up in Taiwan

被引：12

作者：

Chen, Yng-Tay ^{[1
]}

Wei, Chang-Ching ^{[2
]}

Ng, Ka-Lok ^{[3
]}

Chen, Cheng-Hsu ^{[4
]}

Chan, Chia-Jung ^{[1
]}

Chen, Xian-Xiu ^{[1
]}

Chang, Yuan-Yen ^{[5
]}

Chen, Shih-Yin ^{[1
,6
]}

Tsai, Fuu-Jen ^{[1
,3
,6
,7
]}

机构：

[1] China Med Univ Hosp, Dept Med Res, Genet Ctr, Taichung, Taiwan

[2] China Med Univ Hosp, Div Nephrol, Dept Pediat, Taichung, Taiwan

[3] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan

[4] Taichung Vet Gen Hosp, Dept Internal Med, Div Nephrol, Taichung, Taiwan

[5] Chung Shan Med Univ, Dept Microbiol & Immunol, Inst Microbiol & Immunol, Taichung, Taiwan

[6] China Med Univ, Sch Chinese Med, Taichung, Taiwan

[7] China Med Univ Hosp, Dept Med Genet, Taichung, Taiwan

来源：

RENAL FAILURE | 2013年 / 35卷 / 10期

关键词：

Genotype; haplotype; membranous glomerulonephritis; single nucleotide polymorphisms; toll-like receptor 9; GENE POLYMORPHISMS; RENAL-DISEASES; NEPHROPATHY; PROGNOSIS; INSIGHTS; LUPUS; ALPHA; CELLS;

D O I：

10.3109/0886022X.2013.828264

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this study was to determine whether toll-like receptors 9 (TLR9) gene polymorphisms (rs352139 and rs352140) were markers of susceptibility to the development and progression of membranous nephropathy (MGN) in Taiwanese patients. The polymorphisms were investigated by polymerase chain reaction in 397 Taiwanese individuals (134 MGN patients and 263 controls). Patients with malignancy, chronic infectious diseases, lupus nephritis, or drug-induced secondary MGN were excluded from the study. Data showed AA genotype at rs352139 SNP or GG genotype at rs352140 SNP may indicate higher risk for MGN (odds ratio [OR] = 1.55; 95% confidence interval [CI] = 1.02-2.35, at rs352139 SNP; OR 1.57; 95% CI = 1.03-2.39, at rs352140 SNP). However, MGN patients with A-G haplotype were susceptible for decreased creatinine clearance rate and for seriously tubule-interstitial fibrosis. The result suggests for the first time that TLR9 (rs352139 and rs352140) polymorphisms may contribute to the development and progression of MGN.

引用

页码：1370 / 1375

页数：6

共 30 条

[1] Tumor necrosis factor-α gene G-308A polymorphism is a risk factor for the development of membranous glomerulonephritis [J].