New Genetic Abnormalities and Treatment Response in Acute Lymphoblastic Leukemia

被引：32
作者：
Meijerink, Jules P. P. [1 ]
den Boer, Monique L. [1 ]
Pieters, Rob [1 ]
机构：
[1] Sophia Childrens Univ Hosp, Erasmus Med Ctr Rotterdam, Dept Pediat Oncol Hematol, NL-3015 GJ Rotterdam, Netherlands
来源：
SEMINARS IN HEMATOLOGY | 2009年 / 46卷 / 01期
关键词：
VITRO DRUG-RESISTANCE; PEDIATRIC T-ALL; TUMOR-SUPPRESSOR; FLT3; MUTATIONS; CHROMOSOMAL TRANSLOCATIONS; PROGNOSTIC-SIGNIFICANCE; EXPRESSION SIGNATURES; HOX11L2; EXPRESSION; CHILDHOOD; FUSION;
D O I：
10.1053/j.seminhematol.2008.09.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed. © 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：16 / 23
页数：8
相关论文
共 70 条
[51]   In vitro drug resistance profile of Philadelphia positive acute lymphoblastic leukemia is heterogeneous and related to age: A report of the Dutch and German leukemia study groups [J].
Ramakers-van Woerden, NL ;
Pieters, R ;
Hoelzer, D ;
Slater, RM ;
den Boer, ML ;
Loonen, AH ;
Harbott, J ;
Janka-Schaub, GE ;
Ludwig, WD ;
Ossenkoppele, GJ ;
van Wering, ER ;
Veerman, AJP .
MEDICAL AND PEDIATRIC ONCOLOGY, 2002, 38 (06) :379-386
[52]   The multifaceted role of Notch in cancer [J].
Roy, Monideepa ;
Pear, Warren S. ;
Aster, Jon C. .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2007, 17 (01) :52-59
[53]   P16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice [J].
Shank-Calvo, J. A. ;
Draheim, K. ;
Bhasin, M. ;
Kelliher, M. A. .
ONCOGENE, 2006, 25 (21) :3023-3031
[54]   HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (TALL) [J].
Soulier, J ;
Clappier, E ;
Cayuela, JM ;
Regnault, A ;
García-Peydró, M ;
Dombret, H ;
Baruchel, A ;
Toribio, ML ;
Sigaux, F .
BLOOD, 2005, 106 (01) :274-286
[55]   A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias [J].
Speleman, F ;
Cauwelier, B ;
Dastugue, N ;
Cools, J ;
Verhasselt, B ;
Poppe, B ;
Van Roy, N ;
Vandesompele, J ;
Graux, C ;
Uyttebroeck, A ;
Boogaerts, M ;
De Moerloose, B ;
Benoit, Y ;
Selleslag, D ;
Billiet, J ;
Robert, A ;
Huguet, F ;
Vandenberghe, P ;
De Paepe, A ;
Marynen, P ;
Hagemeijer, A .
LEUKEMIA, 2005, 19 (03) :358-366
[56]   Prognostic significance of high-level FLT3 expression in MLL-rearranged infant acute lymphoblastic leukemia [J].
Stam, Ronald W. ;
Schneider, Pauline ;
de Lorenzo, Paola ;
Valsecchi, Maria G. ;
den Boer, Monique L. ;
Pieters, Rob .
BLOOD, 2007, 110 (07) :2774-2775
[57]   Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia [J].
Stam, RW ;
den Boer, ML ;
Schneider, P ;
Nollau, P ;
Horstmann, M ;
Beverloo, HB ;
van der Voort, E ;
Valsecchi, MG ;
de Lorenzo, P ;
Sallan, SE ;
Armstrong, SA ;
Pieters, R .
BLOOD, 2005, 106 (07) :2484-2490
[58]   Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome [J].
Stams, WAG ;
Beverloo, HB ;
den Boer, M ;
de Menezes, R ;
Stigter, R ;
van Drunen, E ;
Ramakers-Van- oerden, NL ;
Loonen, AH ;
van Wering, ER ;
Janka-Schaub, G ;
Pieters, R .
LEUKEMIA, 2006, 20 (03) :410-416
[59]   NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL [J].
Sulis, Maria Luisa ;
Williams, Odette ;
Palomero, Teresa ;
Tosello, Valeria ;
Pallikuppam, Sasikala ;
Real, Pedro J. ;
Barnes, Kelly ;
Zuurbier, Linda ;
Meijerink, Jules P. ;
Ferrando, Adolfo A. .
BLOOD, 2008, 112 (03) :733-740
[60]   The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia [J].
Thompson, Benjamin J. ;
Buonamici, Silvia ;
Sulis, Maria Luisa ;
Palomero, Teresa ;
Vilimas, Tomas ;
Basso, Giuseppe ;
Ferrando, Adolfo ;
Aifantis, Iannis .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1825-1835
1234567