New Genetic Abnormalities and Treatment Response in Acute Lymphoblastic Leukemia

被引：32

作者：

Meijerink, Jules P. P. ^{[1
]}

den Boer, Monique L. ^{[1
]}

Pieters, Rob ^{[1
]}

机构：

[1] Sophia Childrens Univ Hosp, Erasmus Med Ctr Rotterdam, Dept Pediat Oncol Hematol, NL-3015 GJ Rotterdam, Netherlands

来源：

SEMINARS IN HEMATOLOGY | 2009年 / 46卷 / 01期

关键词：

VITRO DRUG-RESISTANCE; PEDIATRIC T-ALL; TUMOR-SUPPRESSOR; FLT3; MUTATIONS; CHROMOSOMAL TRANSLOCATIONS; PROGNOSTIC-SIGNIFICANCE; EXPRESSION SIGNATURES; HOX11L2; EXPRESSION; CHILDHOOD; FUSION;

D O I：

10.1053/j.seminhematol.2008.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed. © 2009 Elsevier Inc. All rights reserved.

引用

页码：16 / 23

页数：8

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