Infantile Inflammatory Myofibroblastic Tumor of Spleen

被引：4

作者：

Thirunavukkarasu, Balamurugan ^{[1
]}

Roy, Pritam Singha ^{[2
]}

Gupta, Kirti ^{[1
]}

Sekar, Aravind ^{[1
]}

Bansal, Deepak ^{[2
]}

机构：

[1] Post Grad Inst Med Educ & Res, Histopathol, 5th Floor,A Block,Sect 12, Chandigarh 160012, India

[2] Post Grad Inst Med Educ & Res, Pediat, Chandigarh, India

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2022年 / 41卷 / 03期

关键词：

Inflammatory myofibroblastic tumor; ALK; Epstein– Barr virus; spleen; ROS1; EPSTEIN-BARR-VIRUS; ROS1; ALK; REARRANGEMENTS; PSEUDOTUMOR; EXPRESSION;

D O I：

10.1080/15513815.2020.1836098

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm with unknown etiology and recurrent potential. They are widely reported in children and young adults. Nearly 50% of inflammatory myofibroblastic tumor harbor rearrangement in anaplastic lymphoma kinase (ALK) gene with the majority expressing ALK protein. ALK-negative IMTs harbor alteration in ROS1 gene in a subset of cases. Few reports have shown association of IMT with Epstein-Barr virus (EBV). Case report: We report a case of IMT of the spleen in an 18-month-old infant presenting with abdominal distention and failure to thrive. Workup for ALK-1, ROS1, and EBV small-encoded RNA in-situ hybridization using immunohistochemistry was negative. Conclusions: IMT can arise in an infant spleen.

引用

页码：475 / 479

页数：5

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