Infantile Inflammatory Myofibroblastic Tumor of Spleen

被引：3
作者：
Thirunavukkarasu, Balamurugan [1 ]
Roy, Pritam Singha [2 ]
Gupta, Kirti [1 ]
Sekar, Aravind [1 ]
Bansal, Deepak [2 ]
机构：
[1] Post Grad Inst Med Educ & Res, Histopathol, 5th Floor,A Block,Sect 12, Chandigarh 160012, India
[2] Post Grad Inst Med Educ & Res, Pediat, Chandigarh, India
来源：
FETAL AND PEDIATRIC PATHOLOGY | 2022年 / 41卷 / 03期
关键词：
Inflammatory myofibroblastic tumor; ALK; Epstein– Barr virus; spleen; ROS1; EPSTEIN-BARR-VIRUS; ROS1; ALK; REARRANGEMENTS; PSEUDOTUMOR; EXPRESSION;
D O I：
10.1080/15513815.2020.1836098
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Background: Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm with unknown etiology and recurrent potential. They are widely reported in children and young adults. Nearly 50% of inflammatory myofibroblastic tumor harbor rearrangement in anaplastic lymphoma kinase (ALK) gene with the majority expressing ALK protein. ALK-negative IMTs harbor alteration in ROS1 gene in a subset of cases. Few reports have shown association of IMT with Epstein-Barr virus (EBV). Case report: We report a case of IMT of the spleen in an 18-month-old infant presenting with abdominal distention and failure to thrive. Workup for ALK-1, ROS1, and EBV small-encoded RNA in-situ hybridization using immunohistochemistry was negative. Conclusions: IMT can arise in an infant spleen.
引用
收藏
页码：475 / 479
页数：5
相关论文
共 16 条
  • [1] Molecular Characterization of Inflammatory Myofibroblastic Tumors With Frequent ALK and ROS1 Gene Fusions and Rare Novel RET Rearrangement
    Antonescu, Cristina R.
    Suurmeijer, Albert J. H.
    Zhang, Lei
    Sung, Yun-Shao
    Jungbluth, Achim A.
    Travis, William D.
    Al-Ahmadie, Hikmat
    Fletcher, Christopher D. M.
    Alaggio, Rita
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (07) : 957 - 967
  • [2] Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor
    Butrynski, James E.
    D'Adamo, David R.
    Hornick, Jason L.
    Dal Cin, Paola
    Antonescu, Cristina R.
    Jhanwar, Suresh C.
    Ladanyi, Marc
    Capelletti, Marzia
    Rodig, Scott J.
    Ramaiya, Nikhil
    Kwak, Eunice L.
    Clark, Jeffrey W.
    Wilner, Keith D.
    Christensen, James G.
    Jaenne, Pasi A.
    Maki, Robert G.
    Demetri, George D.
    Shapiro, Geoffrey I.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (18) : 1727 - 1733
  • [3] Expanding the Molecular Characterization of Thoracic Inflammatory Myofibroblastic Tumors beyond ALK Gene Rearrangements
    Chang, Jason C.
    Zhang, Lei
    Drilon, Alexander E.
    Chi, Ping
    Alaggio, Rita
    Borsu, Laetitia
    Benayed, Ryma
    Travis, William D.
    Ladanyi, Marc
    Antonescu, Cristina R.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (05) : 825 - 834
  • [4] ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor
    Coffin, CM
    Patel, A
    Perkins, S
    Elenitoba-Johnson, KSJ
    Perlman, E
    Griffin, CA
    [J]. MODERN PATHOLOGY, 2001, 14 (06) : 569 - 576
  • [5] Epstein-Barr virus-associated inflammatory pseudotumor presenting as a colonic mass
    Gong, Shunyou
    Auer, Iwona
    Duggal, Rajan
    Pittaluga, Stefania
    Raffeld, Mark
    Jaffe, Elaine S.
    [J]. HUMAN PATHOLOGY, 2015, 46 (12) : 1956 - 1961
  • [6] Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors
    Hornick, Jason L.
    Sholl, Lynette M.
    Dal Cin, Paola
    Childress, Merrida A.
    Lovly, Christine M.
    [J]. MODERN PATHOLOGY, 2015, 28 (05) : 732 - 739
  • [7] Inflammatory myofibroblastic tumor in children diagnosis and treatment
    Karnak, I
    Senocak, ME
    Ciftci, AO
    Çaglar, M
    Bingöl-Kologlu, M
    Tanyel, FC
    Büyükpamukcu, N
    [J]. JOURNAL OF PEDIATRIC SURGERY, 2001, 36 (06) : 908 - 912
  • [8] Inflammatory Myofibroblastic Tumors Harbor Multiple Potentially Actionable Kinase Fusions
    Lovly, Christine M.
    Gupta, Abha
    Lipson, Doron
    Otto, Geoff
    Brennan, Tina
    Chung, Catherine T.
    Borinstein, Scott C.
    Ross, Jeffrey S.
    Stephens, Philip J.
    Miller, Vincent A.
    Coffin, Cheryl M.
    [J]. CANCER DISCOVERY, 2014, 4 (08) : 889 - 895
  • [9] Inflammatory Myofibroblastic Tumors in Childhood
    Mehta, Bhakti
    Mascarenhas, Leo
    Zhou, Shengmei
    Wang, Larry
    Venkatramani, Rajkumar
    [J]. PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2013, 30 (07) : 640 - 645
  • [10] Neuhauser TS, 2001, ARCH PATHOL LAB MED, V125, P379
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