Prenatal diagnosis of chromosomal abnormalities in a resource-poor setting

被引:7
作者
Geerts, Lut [1 ]
机构
[1] Univ Stellenbosch, Dept Obstet & Gynecol, Tygerberg Hosp, Cape Town, South Africa
关键词
Aneuploidy; Prenatal diagnosis; Ultrasound; Low-income country;
D O I
10.1016/j.ijgo.2008.05.028
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To compare the efficacy and efficiency of systematic, ultrasound-based risk adjustment using a published algorithm with that of a maternal age cutoff of 37 years for the prenatal detection of chromosomal abnormalities (especially autosomal trisomies). Methods: These approaches were compared in a retrospective study of 136 chromosomal abnormalities confirmed by karyotyping prenatally (n=46) or postnatally (n=90). There were 114 autosomal trisomies. Results: Maternal age was known for 103 fetuses with confirmed abnormalities. The ultrasound-based risk adjustment approach was more sensitive for autosomal trisomy (93.9% vs 44.1%), and karyotyping for younger women with abnormalities on ultrasound was more effective than routine karyotyping in older women (1 trisomy detected in 13.5 vs 42.8 samples, P < 0.001). A tack of screening was the main reason for the postnatal diagnosis. Conclusion: Ultrasound-based risk adjustment was the more effective approach. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:16 / 21
页数:6
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