Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis

被引：7
作者：
Fernando, Narmada [1 ]
de Silva, Rajiva [2 ]
Handunnetti, Shiroma M. [1 ]
Karunanayake, Lilani [3 ]
de Silva, Nipun Lakshitha [4 ]
de Silva, H. Janaka [5 ]
Rajapakse, Senaka [4 ]
Premawansa, Sunil [6 ]
机构：
[1] Univ Colombo, Inst Biochem Mol Biol & Biotechnol, Colombo, Sri Lanka
[2] Med Res Inst, Dept Immunol, Colombo, Sri Lanka
[3] Med Res Inst, Natl Leptospirosis Reference Lab, Colombo, Sri Lanka
[4] Univ Colombo, Fac Med, Trop Med Res Unit, Colombo, Sri Lanka
[5] Univ Kelaniya, Fac Med, Ragama, Sri Lanka
[6] Univ Colombo, Fac Sci, Colombo, Sri Lanka
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 05期
关键词：
ceftriaxone; inflammatory cytokines; interleukin-8; leptospirosis;
D O I：
10.1128/AAC.02312-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (P = 0.01). IL-6 and IL-8 levels were low in patients who received > 5 antimicrobial doses (P = 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (r = -0.315; P = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.
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