Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease

被引：14
作者：
Takei, A
Honma, S
Kawashima, A
Yabe, I
Fukazawa, T
Hamada, K
Hamada, T
Tashiro, K
机构：
[1] Hokuyukai Neurol Hosp, Nishi Ku, Sapporo, Hokkaido 0630802, Japan
[2] Hokkaido Univ, Sch Med, Dept Neurol, Sapporo, Hokkaido 060, Japan
来源：
PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2002年 / 56卷 / 02期
关键词：
5-HT1A receptor agonist; cerebellar ataxia; depression; Machado-Joseph disease; tandospirone citrate;
D O I：
10.1046/j.1440-1819.2002.00952.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia. We report the first case of a patient with Machado-Joseph disease in which we successfully treated cerebellar ataxia. In addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5-HT1A receptors, were also remarkably alleviated by treatment with tandospirone.
引用
收藏
页码：181 / 185
页数：5
相关论文
共 19 条
  • [1] Sleep/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats
    Bjorvatn, B
    Fagerland, S
    Eid, T
    Ursin, R
    [J]. BRAIN RESEARCH, 1997, 770 (1-2) : 81 - 88
  • [2] DARROW EJ, 1990, EUR J PHARMACOL, V148, P235
  • [3] Machado-Joseph Disease spinocerebellar ataxia 3 responsive to buspirone
    Friedman, JH
    [J]. MOVEMENT DISORDERS, 1997, 12 (04) : 613 - 614
  • [4] PUTATIVE MECHANISMS OF BUSPIRONE-INDUCED ANTINOCICEPTION IN THE RAT
    GIORDANO, J
    ROGERS, L
    [J]. PAIN, 1992, 50 (03) : 365 - 372
  • [5] KANAZAWA I, 1997, RINSYO IYAKU, V13, P4169
  • [6] USE OF BUSPIRONE FOR TREATMENT OF CEREBELLAR-ATAXIA - AN OPEN-LABEL STUDY
    LOU, JS
    GOLDFARB, L
    MCSHANE, L
    GATEV, P
    HALLETT, M
    [J]. ARCHIVES OF NEUROLOGY, 1995, 52 (10) : 982 - 988
  • [7] Maura G, 1996, J NEUROCHEM, V66, P203
  • [8] NOMOTO M, 1997, UNDO SYOGAI, V7, P65
  • [9] SAITO Y, 1998, NAGOYA SHIRITU BYOUI, V21, P5
  • [10] Sleep and waking following microdialysis perfusion of the selective 5-HT1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat
    Sorensen, E
    Gronli, J
    Bjorvatn, B
    Bjorkum, A
    Ursin, R
    [J]. BRAIN RESEARCH, 2001, 897 (1-2) : 122 - 130
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