Exploration the Significance of a Novel Immune-Related Gene Signature in Prognosis and Immune Microenvironment of Breast Cancer

被引：17

作者：

Zhao, Yajie ^{[1
,2
]}

Pu, Chunrui ^{[1
,2
]}

Liu, Zhenzhen ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Dept Breast, Affiliated Canc Hosp, Zhengzhou, Peoples R China

[2] Henan Canc Hosp, Zhengzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

关键词：

bioinformatics; immune; breast cancer; The Cancer Genome Atlas (TCGA); Gene Expression Omnibus (GEO); ENHANCES TUMOR PROGRESSION; MACROPHAGE RESPONSE; SIGNALING PATHWAY; LYMPHOCYTES; TARGET; POLARIZATION; STATISTICS; EXPRESSION; RISK;

D O I：

10.3389/fonc.2020.01211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was designed to identify an immune-related gene signature (IRGS) associated with breast cancer (BC) patient outcomes. Transcriptomic data from 1411 BC patients in the TCGA and GEO databases were used to identify differentially expressed immune-related genes (DEIGs) when comparing BC tumor and normal tissue samples. We were able to construct a 27-gene IRGS that was able to effectively separate BC patients into high- and low-risk groups that corresponded to significant differences in overall and recurrence-free survival (OS and RFS, respectively). Besides, the relevance of this signature to immune response and immune cell infiltration of BC tumors was evaluated. These high- and low-risk BC patients were found to exhibit significantly different immune responses and functional enrichment. We also identified patients in the high-risk group exhibited significantly reduced immune cell infiltration of tumors relative to low-risk patients. Together, the results of this analysis offer a novel overview of the immune microenvironment within BC tumors and highlight key immunological genes associated with patient survival outcomes.

引用

页数：14

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