A liaF Codon Deletion Abolishes Daptomycin Bactericidal Activity against Vancomycin-Resistant Enterococcus faecalis

被引：42

作者：

Munita, Jose M. ^{[1
,2
]}

Tran, Truc T. ^{[1
,5
]}

Diaz, Lorena ^{[1
,4
]}

Panesso, Diana ^{[1
,4
]}

Reyes, Jinnethe ^{[1
,4
]}

Murray, Barbara E. ^{[3
,6
,7
]}

Arias, Cesar A. ^{[1
,3
,4
]}

机构：

[1] Univ Texas Med Sch Houston, Lab Antimicrobial Res, Houston, TX USA

[2] Univ Desarrollo, Sch Med, Clin Alemana, Clin Alemana Santiago, Santiago, Chile

[3] Ctr Study Emerging & Reemerging Pathogens, Div Infect Dis, Dept Internal Med, Houston, TX USA

[4] Univ El Bosque, Mol Genet & Antimicrobial Resistance Unit, Bogota, Colombia

[5] Univ Houston, Coll Pharm, Houston, TX 77030 USA

[6] Univ Texas Med Sch Houston, Lab Enterococcal Res, Houston, TX USA

[7] Univ Texas Med Sch Houston, Dept Microbiol & Mol Genet, Houston, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 06期

关键词：

FAECIUM; ENDOCARDITIS; FAILURE;

D O I：

10.1128/AAC.00021-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

引用

页码：2831 / 2833

页数：3

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