In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity

被引：3
|
作者：
Ohlyan, Renu [1 ]
Kandale, Ajit [2 ]
Deora, Girdhar Singh [3 ]
Rathore, Vandana [4 ]
Chahal, Jagbir [1 ]
机构：
[1] MM Coll Pharm, Ambala 133207, Haryana, India
[2] Natl Inst Ayurved Pharmaceut Res, Patiala 147001, Punjab, India
[3] Rajiv Gandhi Proudyogiki Vishwavidyalaya, Sch Pharmaceut Sci, Bhopal 460023, India
[4] BN Girls Coll Pharm, Udaipur 313002, Rajasthan, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 03期
关键词：
Piper attenuatum; Anticancer; MCF7 cell lines; Antioxidant; ABTS assay; INDIAN MEDICINAL-PLANTS;
D O I：
10.1007/s00044-012-0122-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Indian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antioxidant and anticancer activity. Three extracts were prepared using ethyl acetate, ethanol and methanol. In vitro antioxidant activity was performed by ABTS {2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)} free radical scavenging method. All three extracts reduced the free radicals produced by ABTS in a concentration-dependent manner which could be compared to the standard (gallic acid). Invitro anticancer activity of all extracts was carried out by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay method against MCF7 (Michigan Cancer Foundation-7) cell lines. None of the extract showed anticancer activity when compared with the standard (mitomycin C) indicating that P. attenuatum is deprived of antiproliferative or cytotoxic components.
引用
收藏
页码：1365 / 1370
页数：6
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