In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity

被引：3

作者：

Ohlyan, Renu ^{[1
]}

Kandale, Ajit ^{[2
]}

Deora, Girdhar Singh ^{[3
]}

Rathore, Vandana ^{[4
]}

Chahal, Jagbir ^{[1
]}

机构：

[1] MM Coll Pharm, Ambala 133207, Haryana, India

[2] Natl Inst Ayurved Pharmaceut Res, Patiala 147001, Punjab, India

[3] Rajiv Gandhi Proudyogiki Vishwavidyalaya, Sch Pharmaceut Sci, Bhopal 460023, India

[4] BN Girls Coll Pharm, Udaipur 313002, Rajasthan, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 03期

关键词：

Piper attenuatum; Anticancer; MCF7 cell lines; Antioxidant; ABTS assay; INDIAN MEDICINAL-PLANTS;

D O I：

10.1007/s00044-012-0122-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Indian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antioxidant and anticancer activity. Three extracts were prepared using ethyl acetate, ethanol and methanol. In vitro antioxidant activity was performed by ABTS {2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)} free radical scavenging method. All three extracts reduced the free radicals produced by ABTS in a concentration-dependent manner which could be compared to the standard (gallic acid). Invitro anticancer activity of all extracts was carried out by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay method against MCF7 (Michigan Cancer Foundation-7) cell lines. None of the extract showed anticancer activity when compared with the standard (mitomycin C) indicating that P. attenuatum is deprived of antiproliferative or cytotoxic components.

引用

页码：1365 / 1370

页数：6

共 50 条

[1] In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity
Renu Ohlyan
Ajit Kandale
Girdhar Singh Deora
Vandana Rathore
Jagbir Chahal
Medicinal Chemistry Research, 2013, 22 : 1365 - 1370
[2] Standardization and In Vivo Antioxidant Activity of Ethanol Extracts of Fruit and Leaf of Piper sarmentosum
Hussain, Khalid
Ismail, Zhari
Sadikun, Amirin
Ibrahim, Pazilah
PLANTA MEDICA, 2010, 76 (05) : 418 - 425
[3] In vitro anticancer activity of fruit extracts from Vaccinium species
Bomser, J
Madhavi, DL
Singletary, K
Smith, MAL
PLANTA MEDICA, 1996, 62 (03) : 212 - 216
[4] EVALUATION OF TOTAL PHENOLIC, FLAVANOID AND IN VITRO ANTIOXIDANT ACTIVITY OF DIFFERENT EXTRACTS OF PIPER NIGRUM
Foyzun, Tahira
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 3 (09): : 974 - 983
[5] Phytochemical screening along with in vitro antioxidant, antibacterial and anticancer activity of Senna auriculata (L.) bark extracts
Revathi, Seemaisamy
Altemimi, Ammar B.
Sutikno, Sutikno
Cacciola, Francesco
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, 2024,
[6] Antioxidant activity of Garcinia xanthochymus leaf, root and fruit extracts in vitro
Fu Meng
Feng Hui-Jin
Chen Yu
Wang De-Bin
Yang Guang-Zhong
CHINESE JOURNAL OF NATURAL MEDICINES, 2012, 10 (02) : 129 - 134
[7] Screening of Antibacterial Activity, Antioxidant Activity, and Anticancer Activity of Euphorbia hirta Linn. Extracts
Ngan Tran
Minh Nguyen
Le, Khanh P. B.
Nhi Nguyen
Quan Tran
Ly Le
APPLIED SCIENCES-BASEL, 2020, 10 (23): : 1 - 15
[8] PHYTOCHEMICAL SCREENING AND IN-VITRO ANTICANCER ACTIVITY OF EXTRACTS OF TECTARIA CICUTARIA
Preeti, Karade
Namdeo, Jadhav
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2018, 9 (08): : 3463 - 3468
[9] Antioxidant and antibacterial activity of the extracts of Piper cubeba ( Piperaceae)
Chitnis, R.
Abichandani, M.
Nigam, P.
Nahar, L.
Sarker, S. D.
ARS PHARMACEUTICA, 2007, 48 (04) : 343 - 350
[10] Phytochemical screening, antioxidant and in vitro anticancer activities of Bombax buonopozense stem bark extracts
Tilaoui, Mounir
Achibat, Hanane
Lebri, Marius
Lagou, Stephanie
Mouse, Hassan Ait
Zazouli, Sofia
Hafid, Abderrafia
Zyad, Abdelmajid
Khouili, Mostafa
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2021, 35 (01) : 1662 - 1668

← 1 2 3 4 5 →