Zinc-finger proteins in health and disease

被引：562

作者：

Cassandri, Matteo ^{[1
]}

Smirnov, Artem ^{[1
]}

Novelli, Flavia ^{[1
]}

Pitolli, Consuelo ^{[1
]}

Agostini, Massimiliano ^{[1
]}

Malewicz, Michal ^{[2
]}

Melino, Gerry ^{[1
,2
]}

Raschella, Giuseppe ^{[3
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Surg, I-00133 Rome, Italy

[2] Univ Leicester, Toxicol Unit, Med Res Council, Leicester LE1 9HN, Leics, England

[3] ENEA Res Ctr Casaccia, Lab Biosafety & Risk Assessment, Via Anguillarese, Rome, Italy

来源：

CELL DEATH DISCOVERY | 2017年 / 3卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/cddiscovery.2017.71

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of several cellular processes. In fact, ZNFs are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, actin targeting, DNA repair, cell migration, and numerous other processes. The aim of this review is to provide a comprehensive summary of the current state of knowledge of this class of proteins. Firstly, we describe the actual classification of ZNFs, their structure and functions. Secondly, we focus on the biological role of ZNFs in the development of organisms under normal physiological and pathological conditions.

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