Low Wall Shear Stress Is Independently Associated With the Rupture Status of Middle Cerebral Artery Aneurysms

被引：189

作者：

Miura, Yoichi ^{[1
]}

Ishida, Fujimaro ^{[2
]}

Umeda, Yasuyuki ^{[1
]}

Tanemura, Hiroshi ^{[2
]}

Suzuki, Hidenori ^{[1
]}

Matsushima, Satoshi ^{[1
]}

Shimosaka, Shinichi ^{[2
]}

Taki, Waro ^{[1
]}

机构：

[1] Mie Univ, Dept Neurosurg, Grad Sch Med, Tsu, Mie 514, Japan

[2] Natl Hosp Org, Dept Neurosurg, Mie Chuo Med Ctr, Tsu, Mie 5141101, Japan

来源：

STROKE | 2013年 / 44卷 / 02期

关键词：

computational fluid dynamics analysis; middle cerebral artery aneurysm; wall shear stress; CAROTID-ARTERY; HEMODYNAMICS; FLOW;

D O I：

10.1161/STROKEAHA.112.675306

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-We determined which hemodynamic parameter independently characterizes the rupture status of middle cerebral artery (MCA) aneurysms using computational fluid dynamics analysis. Methods-In 106 patient-specific geometries of MCA aneurysms (43 ruptured, 63 unruptured), morphological and hemodynamic parameters were compared between the ruptured and unruptured groups. Multivariate logistic regression analysis was performed to determine parameters that independently characterized the rupture status of MCA aneurysms. Results-Univariate analyses showed that the aspect ratio, wall shear stress (WSS), normalized WSS, oscillatory shear index, WSS gradient, and aneurysm-formation index were significant parameters. The size of the aneurysmal dome and the gradient oscillatory number were not significantly different between the 2 groups. With multivariate analyses, only lower WSS was significantly associated with the rupture status of MCA aneurysms. Conclusions-WSS may be the most reliable parameter characterizing the rupture status of MCA aneurysms. (Stroke. 2013;44:519-521.)

引用

页码：519 / +

页数：8

共 12 条

[1] Aneurysm Growth Occurs at Region of Low Wall Shear Stress Patient-Specific Correlation of Hemodynamics and Growth in a Longitudinal Study [J].