Perioperative desmopressin prolongs survival in surgically treated bitches with mammary gland tumours: A pilot study

被引：33

作者：

Hermo, Guillermo A. ^{[1
]}

Torres, Perla ^{[2
]}

Ripoll, Giselle V. ^{[1
]}

Scursoni, Alejandra M. ^{[1
,4
]}

Gomez, Daniel E. ^{[1
]}

Alonso, Daniel F. ^{[1
]}

Gobello, Cristina ^{[3
]}

机构：

[1] Quilmes Natl Univ, Dept Sci & Technol, Mol Oncol Lab, Quilmes, Buenos Aires, Argentina

[2] La Pampa Natl Univ, Fac Vet Med, Santa Rosa, Argentina

[3] Natl Univ La Plata, Fac Vet Med, La Plata, Buenos Aires, Argentina

[4] Garrahan Hosp, Dept Pathol, Buenos Aires, DF, Argentina

来源：

VETERINARY JOURNAL | 2008年 / 178卷 / 01期

关键词：

Desmopressin; Canine; Mammary tumours; Metastasis;

D O I：

10.1016/j.tvjl.2007.06.015

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Desmopressin (1-deamino-8-D-arginine vasopressin, also known as DDAVP) is a safe haemostatic compound capable of inhibiting lymph node and lung metastasis in a mouse model of mammary tumour manipulation and surgical excision. The aim of this Study was to test the efficacy and safety of perioperative DDAVP (1 mu g/kg) in surgically treated bitches with mammary gland tumours (MGT). Twenty-one, otherwise healthy, intact bitches, with malignant MGT stage III or IV were randomly allocated to DDAVP (n = 11) or placebo (n = 10) groups. En bloc mastectomy of the affected gland/s was performed. DDAVP had a significant beneficial effect on disease-free period (P < 0.01) and overall survival time (P < 0.05). No side effects were seen in any of the cases. Whatever the mechanism of action, it seems that DDAVP may have a novel use in cancer surgery to minimise spread or survival of residual malignant cells. Additional, large scale controlled trials are required to fully evaluate this adjuvant pharmacological protocol. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：103 / 108

页数：6

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