Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

被引：3
作者：
Ham, Sin Young [1 ,2 ]
Jung, Hyungul [1 ]
Song, Kyoung-Ho [1 ,3 ]
Jeong, Hyeonju [1 ]
Jung, Jongtak [1 ]
Moon, Song Mi [1 ,3 ]
Park, Jeong Su [4 ]
Kim, Nak-Hyun [1 ]
Jang, Eun Sun [1 ,3 ]
Kim, Jin-Wook [1 ,3 ]
Jeong, Sook-Hyang [1 ,3 ]
Kim, Eu Suk [1 ,3 ]
Bin Kim, Hong [1 ,3 ]
机构：
[1] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Infect Dis, 82 Gumi Ro 173beon Gil, Seongnam 13620, Gyeonggi Do, South Korea
[2] Korea Vet Hosp, Dept Internal Med, Seoul, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[4] Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam, South Korea
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2022年 / 41卷 / 12期
关键词：
Third-generation cephalosporin resistance; Interspecies difference; Bloodstream infection; Liver cirrhosis; Mortality; Enterobacteriaceae; LACTAMASE; TRANSMISSION; PREVALENCE; ENTEROBACTERIACEAE; EPIDEMIOLOGY; BACTEREMIA; OUTCOMES;
D O I：
10.1007/s10096-022-04508-2
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and beta-lactam/fluoroquinolone treatment <= 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.
引用
收藏
页码：1459 / 1465
页数：7
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