Implantable Self-Powered Low-Level Laser Cure System for Mouse Embryonic Osteoblasts Proliferation and Differentiation

被引：139
作者：
Tang, Wei [1 ]
Tian, Jingjing [1 ]
Zheng, Qiang [1 ]
Yan, Lin [2 ]
Wang, Jiangxue [2 ]
Li, Zhou [1 ]
Wang, Zhong Lin [1 ,3 ]
机构：
[1] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 100083, Peoples R China
[2] Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
[3] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA
来源：
ACS NANO | 2015年 / 9卷 / 08期
基金：
北京市自然科学基金; 中国博士后科学基金;
关键词：
self-powered; low-level laser; embryonic osteoblast; proliferation; differentiation; TRIBOELECTRIC NANOGENERATOR; MC3T3-E1; CELLS; BONE REPAIR; IN-VITRO; THERAPY; ENERGY; EXPRESSION; GENERATOR; RATS; TRANSPARENT;
D O I：
10.1021/acsnano.5b03567
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Bone remodeling or orthodontic treatment is usually a long-term process. It is highly desirable to speed up the process for effective medical treatment. In this work, a self-powered low-level laser cure system for osteogenesis is developed using the power generated by the triboelectric nanogenerator. It is found that the system significantly accelerated the mouse embryonic osteoblasts' proliferation and differentiation, which is essential for bone and tooth healing. The system is further demonstrated to be driven by a living creature's motions, such as human walking or a mouse's breathing, suggesting its practical use as a portable or implantable clinical cure for bone remodeling or orthodontic treatment.
引用
收藏
页码：7867 / 7873
页数：7
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