AR Expression Correlates with Distinctive Clinicopathological and Genomic Features in Breast Cancer Regardless of ESR1 Expression Status

被引：3
|
作者：
Long, Mengping [1 ]
You, Chong [2 ]
Song, Qianqian [3 ]
Hu, Lina X. J. [4 ]
Guo, Zhaorong [5 ]
Yao, Qian [1 ]
Hou, Wei [1 ]
Sun, Wei [1 ]
Liang, Baosheng [3 ]
Zhou, Xiaohua [2 ,3 ]
Liu, Yiqiang [1 ]
Hu, Taobo [2 ,6 ]
机构：
[1] Peking Univ, Dept Pathol, Canc Hosp, Beijing 100083, Peoples R China
[2] Peking Univ, Chongqing Res Inst Big Data, Chongqing 401121, Peoples R China
[3] Peking Univ, Sch Publ Hlth, Dept Biostat, Beijing 100191, Peoples R China
[4] Alaska Native Med Ctr, Dept Pathol, Anchorage, AK 99501 USA
[5] Peking Univ, Dept Breast Ctr, Canc Hosp, Beijing 100083, Peoples R China
[6] Peking Univ Peoples Hosp, Dept Breast Surg, Beijing 100044, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期
基金：
中国国家自然科学基金;
关键词：
androgen receptor; estrogen receptor; breast cancer; molecular feature; ANDROGEN RECEPTOR EXPRESSION; PROGNOSIS; TUMORS;
D O I：
10.3390/ijms231911468
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Androgen receptor (AR) expression is frequently observed in breast cancer, but its association with estrogen receptor (ER) expression in breast cancer remains unclear. This study analyzed the clinicopathological and molecular features associated with AR negativity in both ER-positive and ER-negative breast cancer, trying to elucidate the molecular correlation between AR and ER. Our results showed that AR negativity was associated with different clinicopathological characteristics and molecular features in ER-positive and ER-negative breast cancer. Moreover, AR-positive breast cancer has better clinicopathological features than AR-negative breast cancer, especially in the ER-negative subtype. These results suggest that the role of AR in ER-negative breast cancer is distinctive from that in ER-positive breast cancer.
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收藏
页数：14
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