Plasmonic carbon nanohybrids for repetitive and highly localized photothermal cancer therapy

被引：17

作者：

Chauhan, Deepak S. ^{[1
]}

Kumawat, Mukesh K. ^{[1
]}

Prasad, Rajendra ^{[1
]}

Reddy, Pradeep K. ^{[1
]}

Dhanka, Mukesh ^{[1
]}

Mishra, Sumit K. ^{[2
]}

Bahadur, Rohan ^{[1
]}

Neekhra, Suditi ^{[1
]}

De, Abhijit ^{[2
]}

Srivastava, Rohit ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Biosci & Bioengn, Powai 400076, Mumbai, India

[2] Tata Mem Hosp, ACTREC, Mol Funct Imaging Lab, Kharghar 410210, Navi Mumbai, India

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2018年 / 172卷

关键词：

Graphene; Plasmonic nanomaterials; Photothennal therapy; NIR dyes; Drug leaching; GRAPHENE QUANTUM DOTS; GOLD NANOSHELLS; IR-780; DYE; IN-VITRO; NANOPARTICLES; OXIDE; DELIVERY; SILICA; LIGHT;

D O I：

10.1016/j.colsurfb.2018.08.054

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Integrating metallic and non-metallic platform for cancer nanomedicine is a challenging task and bringing together multi-functionality of two interfaces is a major hurdle for biomaterial design. Herein, NIR light responsive advanced hybrid plasmonic carbon nanomaterials are synthesized, and their properties toward repetitive and highly localized photothermal cancer therapy are well understood. Graphene oxide nanosheets having thickness of similar to 2 nm are synthesized using modified Hummers' method, thereafter functionalized with biodegradable NIR light responsive gold deposited plasmonic polylactic-co-glycolic acid nanoshells (AuPLGA NS, tuned at 808 nm) and NIR dye (IR780) to examine their repetitive and localized therapeutic efficacy as well resulting side effects to nearby healthy cells. It is observed that AuPLGA NS decorated graphene oxide nanosheets (GO-AuPLGA) and IR780 loaded graphene oxide nanosheets (GO-IR780) are capable in standalone complete photothermal ablation of cancer cells within 4 min. of 808 nm NIR laser irradiation and also without the aid of any anticancer drugs. However, GO-AuPLGA having the potential for repetitive photothermal treatment of a big tumor, ablate the cancer cells in highly localized fashion, without having side effects on neighboring healthy cells.

引用

页码：430 / 439

页数：10

共 55 条

[1] Fluorescent carbon nanodots for targeted in vitro cancer cell imaging [J].

Aiyer, Sandhya ;

Prasad, Rajendra ;

Kumar, Manoj ;

Niryikar, K. ;

Jain, Bhanprakash ;

Kushwaha, Omkar S. .

APPLIED MATERIALS TODAY, 2016, 4 :71-77

[2] Enhanced absorption induced by a metallic nanoshell [J].

Baer, R ;

Neuhauser, D ;

Weiss, S .

NANO LETTERS, 2004, 4 (01) :85-88

[3]

Balapanuru J., 2010, Angew. Chem, V122, P6699, DOI DOI 10.1002/ANGE.201001004

[4] Theranostic Nanoshells: From Probe Design to Imaging and Treatment of Cancer [J].

Bardhan, Rizia ;

Lal, Surbhi ;

Joshi, Amit ;

Halas, Naomi J. .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :936-946

[5]

Chauhan Deepak Singh, 2015, 2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED). Proceedings, P143, DOI 10.1109/NANOMED.2015.7492510

[6] Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy [J].

Chauhan, Deepak S. ;

Arunkumar, P. ;

Prasad, Rajendra ;

Mishra, Sumit Kumar ;

Reddy, B. Pradeep K. ;

De, Abhijit ;

Srivastava, Rohit .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2018, 90 :539-548

[7] Disintegrable NIR Light Triggered Gold Nanorods Supported Liposomal Nanohybrids for Cancer Theranostics [J].

Chauhan, Deepak S. ;

Prasad, Rajendra ;

Devrukhkar, Janhavi ;

Selvaraj, Kaliaperumal ;

Srivastava, Rohit .

BIOCONJUGATE CHEMISTRY, 2018, 29 (05) :1510-1518

[8] NIR light-triggered shrinkable thermoresponsive PNVCL nanoshells for cancer theranostics [J].

Chauhan, Deepak S. ;

Indulekha, S. ;

Gottipalli, Rupesh ;

Reddy, B. Pradeep K. ;

Chikate, Tanmayee R. ;

Gupta, Ramkrishn ;

Jahagirdar, Dushyant N. ;

Prasad, Rajendra ;

De, Abhijit ;

Srivastava, Rohit .

RSC ADVANCES, 2017, 7 (70) :44026-44034

[9] A NEW HYDROSOL OF GOLD CLUSTERS .2. A COMPARISON OF SOME DIFFERENT MEASUREMENT TECHNIQUES [J].

DUFF, DG ;

BAIKER, A ;

GAMESON, I ;

EDWARDS, PP .

LANGMUIR, 1993, 9 (09) :2310-2317

[10] PHYSIOLOGICAL-MECHANISMS IN HYPERTHERMIA - A REVIEW [J].

EMAMI, B ;

SONG, CW .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (02) :289-295

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