Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success

被引：12

作者：

Pablo Jaworski, Juan ^{[1
,2
]}

Vendrell, Alejandrina ^{[3
]}

Matias Chiavenna, Sebastian ^{[4
]}

机构：

[1] Natl Sci & Tech Res Council, Buenos Aires, DF, Argentina

[2] Natl Inst Agr Technol, Inst Virol, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Pharmacol & Bot Study Ctr, Sch Med, Buenos Aires, DF, Argentina

[4] Ferrer Adv Biotherapeut, Barcelona, Spain

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 7卷

关键词：

human immunodeficiency virus; neutralizing antibodies; treatment; prophylaxis; reservoir; vaccine; HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL DEPLETION; PROXIMAL EXTERNAL REGION; MUCOSAL SHIV CHALLENGE; N-GLYCAN RECOGNITION; B-CELLS; POTENT NEUTRALIZATION; BISPECIFIC ANTIBODIES; PASSIVE TRANSFER; CONFORMATIONAL EPITOPE;

D O I：

10.3389/fimmu.2016.00661

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre-and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells.

引用

页数：11

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