Use of nitric oxide synthase inhibitors to treat septic shock: The light has changed from yellow to red

被引:40
作者
Cobb, JP [1 ]
机构
[1] Washington Univ, Cellular Injury & Adaptat Lab, St Louis, MO USA
关键词
sepsis; nitric oxide synthase; N-G-methyl-L-arginine; hypotension treatment;
D O I
10.1097/00003246-199905000-00002
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:855 / 856
页数:2
相关论文
共 21 条
[1]  
COBB JP, 1993, CRIT CARE MED, V21, P1261
[2]   DIFFERENTIAL HEMODYNAMIC-EFFECTS OF L-NMMA IN ENDOTOXEMIC AND NORMAL DOGS [J].
COBB, JP ;
NATANSON, C ;
QUEZADO, ZMN ;
HOFFMAN, WD ;
KOEV, CA ;
BANKS, S ;
CORREA, R ;
LEVI, R ;
ELIN, RJ ;
HOSSEINI, JM ;
DANNER, RL .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 268 (04) :H1634-H1642
[3]   Nitric oxide and septic shock [J].
Cobb, JP ;
Danner, RL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (15) :1192-1196
[4]  
COBB JP, IN PRESS SURGERY
[5]   Nitric oxide inhibits stress-induced endothelial cell apoptosis [J].
DeMeester, SL ;
Qiu, YY ;
Buchman, TG ;
Hotchkiss, RS ;
Dunnigan, K ;
Karl, IE ;
Cobb, JP .
CRITICAL CARE MEDICINE, 1998, 26 (09) :1500-1509
[6]   Just say no to NO center dot, yes? [J].
Fink, MP .
CRITICAL CARE MEDICINE, 1996, 24 (11) :1772-1774
[7]   Nitric oxide synthase as a therapeutic target in sepsis - More questions than answers? [J].
Freeman, BD ;
Cobb, JP .
CRITICAL CARE MEDICINE, 1998, 26 (09) :1469-1470
[8]   Response of the septic vasculature to prolonged vasopressor therapy with Nω-monomethyl-L-arginine and epinephrine in canines [J].
Freeman, BD ;
Zeni, F ;
Banks, SM ;
Eichacker, PQ ;
Bacher, JD ;
Garvey, EP ;
Tuttle, JV ;
Jurgensen, CH ;
Natanson, C ;
Danner, RL .
CRITICAL CARE MEDICINE, 1998, 26 (05) :877-886
[9]   Multi-center, randomized, placebo-controlled, double blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock [J].
Grover, R ;
Lopez, A ;
Lorente, J ;
Steingrub, J ;
Bakker, J ;
Willatts, S ;
McLuckie, A ;
Takala, J .
CRITICAL CARE MEDICINE, 1999, 27 (01) :A33-A33
[10]   An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyI-L-arginine hydrochloride (546C88), in patients with septic shock [J].
Grover, R ;
Zaccardelli, D ;
Colice, G ;
Guntupalli, K ;
Watson, D ;
Vincent, JL .
CRITICAL CARE MEDICINE, 1999, 27 (05) :913-922