A role for Myc in facilitating transcription activation by E2F1

被引：76
|
作者：
Leung, J. Y. [1 ]
Ehmann, G. L. [1 ]
Giangrande, P. H. [1 ]
Nevins, J. R. [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Duke Inst Genome Sci & Policy, Durham, NC 27710 USA
来源：
ONCOGENE | 2008年 / 27卷 / 30期
关键词：
E2F1; Myc; promoter; transcription activation;
D O I：
10.1038/onc.2008.55
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous work has demonstrated that E2F proteins regulate the expression of various genes encoding proteins essential for DNA replication and cell-cycle progression. E2F1 in particular is required for the initial entry to the cell cycle from a quiescent state and is required for the activation of other E2F genes. Other work has demonstrated a role for the Myc transcription factor in the activation of a large number of genes associated with cell growth, including E2F genes. We now show that Myc is required to allow the interaction of the E2F1 protein with the E2F gene promoters. As such, Myc thus provides a link between the development of a growth-competent state during the initial stage of G1 and the activation of genes essential for DNA replication at G1/S.
引用
收藏
页码：4172 / 4179
页数：8
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