Predictive and prognostic markers of endometrial cancer

Within the last years a reliable number of studies have analysed predictive and prognostic factors fort the definition of biologically similar subgroups, testing treatment results and for the definition of tailored therapy approaches in patients affected by endometrial cancer (EC). Several studies have demonstrated the prognostic and therapeutic impact of lymph node status, histological tumor type (type 1 vs. type 2 cancers), histological grade, stage of disease, depth of myometrial invasion, lymphovascular space involvement and cervical involvement. Understanding pathogenesis at the molecular level is essential in identifying biomarkers for successful targeted therapies. New parameters and gene expression analysis are identifying different types of endometrial cancer with different prognoses, but theses data are still provisory.