Adipose-derived stem cells for wound healing

被引:145
|
作者
Hassanshahi, Alireza [1 ]
Hassanshahi, Mohammadhossein [2 ]
Khabbazi, Samira [2 ]
Hosseini-Khah, Zahra [3 ]
Peymanfar, Yaser [2 ]
Ghalamkari, Saman [4 ]
Su, Yu-Wen [2 ]
Xian, Cory J. [2 ]
机构
[1] Islamic Azad Univ, Dept Genet, Fac Basic Sci, Shahrekord, Iran
[2] Univ South Australia, Sch Pharm & Med Sci, Canc Res Inst, GPOB 2471, Adelaide, SA 5001, Australia
[3] Mazandaran Univ Med Sci, Dept Immunol, Sch Med, Sari, Iran
[4] Islamic Azad Univ, Dept Biol, Arsanjan, Iran
基金
英国医学研究理事会;
关键词
adipose-derived stem cells; angiogenesis; mesenchymal stem cells; stem cells; stromal vascular fraction; wound healing; STROMAL-VASCULAR FRACTION; PLATELET-RICH PLASMA; COMPLEX PERIANAL FISTULA; ASSISTED LIPOTRANSFER; IN-VIVO; BIOLOGICAL CHARACTERISTICS; REGENERATIVE CELLS; GRAFT-SURVIVAL; BONE-MARROW; TISSUE;
D O I
10.1002/jcp.27922
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells for wound healing, adipose-derived stem cells (ASCs) seem to possess the least limitations for clinical applications, and literature showed that ASCs can improve the process of wound healing very likely by promoting angiogenesis and/or vascularisation, modulating immune response, and inducing epithelialization in the wound. In the present review, advantages and disadvantages of various stem cells which can be used for promoting wound healing are discussed. In addition, potential mechanisms of action by which ASCs may accelerate wound healing are summarised. Finally, clinical studies applying ASCs for wound healing and the associated limitations are reviewed.
引用
收藏
页码:7903 / 7914
页数:12
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